SB 203580, p38 MAPK inhibitor (ab120162)
Key features and details
- p38 MAPK inhibitor
- CAS Number: 152121-47-6
- Purity: > 99%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SB 203580, p38 MAPK inhibitor -
製品の詳細
p38 MAPK inhibitor -
生理活性の詳細
Cell-permeable p38 MAPK inhibitor. Shows selectivity over many other kinases but also shown to have some inhibitory activity against GAK, CK1, RIP2, c-Raf and GSK3.
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精製度
> 99% -
CAS 番号
152121-47-6 -
構造式
製品の特性
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体系名
4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine -
分子量
377.43 -
分子式
C21H16FN3OS -
PubChem 登録番号
176155 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 25 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CS(=O)c1ccc(cc1)c2nc(c(n2)c3ccncc3)c4ccc(F)cc4 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (29)
ab120162 は 29 報の論文で使用されています。
- Liu X et al. Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway. Antioxidants (Basel) 12:N/A (2023). PubMed: 36671037
- Zhu X et al. PSKH1 affects proliferation and invasion of osteosarcoma cells via the p38/MAPK signaling pathway. Oncol Lett 25:144 (2023). PubMed: 36936027
- Guo P et al. Estrogen Suppresses Cytokines Release in cc4821 Neisseria meningitidis Infection via TLR4 and ERβ-p38-MAPK Pathway. Front Microbiol 13:834091 (2022). PubMed: 35422784
- Alsamri H et al. Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells. Front Oncol 12:911615 (2022). PubMed: 35712465
- Zhang J et al. TGF-ß1-induced autophagy activates hepatic stellate cells via the ERK and JNK signaling pathways. Int J Mol Med 47:256-266 (2021). PubMed: 33236148