Anti-SALL1 抗体 [K9814] (ab41974)
Key features and details
- Mouse monoclonal [K9814] to SALL1
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG2a
製品の概要
-
製品名
Anti-SALL1 antibody [K9814]
SALL1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [K9814] to SALL1 -
由来種
Mouse -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Mouse -
免疫原
Baculovirus-expressed recombinant fragment, corresponding to amino acids 258/499 of Human SALL1
-
特記事項
This product was changed from ascites to tissue culture supernatant on 3rd April 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
-
精製度
Tissue culture supernatant -
ポリ/モノ
モノクローナル -
クローン名
K9814 -
ミエローマ
NS1 -
アイソタイプ
IgG2a -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab41974の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P | (1) |
Use at an assay dependent concentration.
|
特記事項 |
---|
IHC-P
Use at an assay dependent concentration. |
ターゲット情報
-
機能
Transcriptional repressor involved in organogenesis. -
組織特異性
Highest levels in kidney. Lower levels in adult brain (enriched in corpus callosum, lower expression in substantia nigra) and liver. -
関連疾患
Defects in SALL1 are the cause of Townes-Brocks syndrome (TBS) [MIM:107480]. TBS is a rare, autosomal dominant malformation syndrome with a combination of imperforate anus, triphalangeal and supernumerary thumbs, malformed ears and sensorineural hearing loss.
Defects in SALL1 may cause a phenotype overlapping with TBS, similar to bronchio-oto-renal syndrome (BOR) [MIM:113650]. BOR is an autosomal dominant disorder, manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to Mondini type cochlear defect and stapes fixation. -
配列類似性
Belongs to the sal C2H2-type zinc-finger protein family.
Contains 9 C2H2-type zinc fingers. -
発生段階
In fetal brain exclusively in neurons of the subependymal region of hypothalamus lateral to the third ventricle. -
細胞内局在
Nucleus. - Information by UniProt
-
参照データベース
- Entrez Gene: 58198 Mouse
- SwissProt: Q9ER74 Mouse
- Unigene: 214361 Mouse
-
別名
- HSal1 antibody
- Sal like protein 1 antibody
- Sal-1 antibody
see all
画像
-
Ab41974 staining SALL1 in Mouse embryonic kidney at tissue sections by Immunohistochemistry (IHC- P- paraformaldehyde-fixed, paraffin- embedded sections). Tissue was fixed with paraformaldehyde and blocked with 10µg/ml BSA for 1 hour at 25oC; antigen retrieval was by heat mediation in a Tris/EDTA (pH9). Samples were incubated with primary antibody (1/100 with 6% Horse serum in PBST) for 16hours at 4oC. An Alexa Fluor® 568 donkey anti-mouse polyclonal (1/500 dilution) was used as the secondary antibody.
This image was generated using the ascites version of the product.
-
ab41974 staining SALL1 in Mouse embryo kidnet tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
This image was generated using the ascites version of the product.
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (5)
ab41974 は 5 報の論文で使用されています。
- Qiu Z et al. The significance of glycolysis index and its correlations with immune infiltrates in Alzheimer's disease. Front Immunol 13:960906 (2022). PubMed: 36353631
- Pantier R et al. SALL4 controls cell fate in response to DNA base composition. Mol Cell 81:845-858.e8 (2021). PubMed: 33406384
- Qian C et al. Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis. Pathol Oncol Res 27:587130 (2021). PubMed: 34257535
- Hernandez JOR et al. A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo. Nat Commun 12:6496 (2021). PubMed: 34764250
- Salman H et al. SALL1 expression in acute myeloid leukemia. Oncotarget 9:7442-7452 (2018). PubMed: 29484122