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Read our guarantee »Overview
Product name
RuBi-GABA
Description
Novel caged-GABA compound, uncaged by visible light
Biological description
Novel caged-GABA compound that uses a ruthenium complex as photosensor. Can be excited with visible wavelengths, providing greater tissue penetration, less photo-toxicity, and faster photorelease kinetics than other UV light-sensitive caged compounds. Can be used for GABA receptor mapping, and optical silencing of neuronal firing.
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
RuBi-GABA is light senstive and it is recommended that the compound is protected from light.
Sold under license from Columbia University; Patent Pending
Properties
Chemical name
(Bis(2,2'-bipyridine-N,N')triphenylphosphine)-4-aminobutyric acid ruthenium hexafluorophosphate complex
Molecular Weight
922.80
Chemical structure
Molecular formula
C42H39N5O2PRu.PF6
Solubility
Soluble in water to 10 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Pharmacology >> Receptors & Transporters >> GABA >> Non-selective >> Agonists
Biochemicals >> Chemical Type >> Caged Compounds
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Chemical Type >> Amino Acid
Biochemicals >> Product Range >> Just Add Water
Protocols
References for RuBi-GABA (ab120409)
This product has been referenced in:
- Zayat L et al. A new inorganic photolabile protecting group for highly efficient visible light GABA uncaging. Chembiochem 8:2035-8 (2007).Read more (PubMed: 17939147) »
- Newton G AIDS and the orthopaedic surgeon. J Bone Joint Surg Br 73:707-8 (1991).Read more (PubMed: 1894654) »
See all 3 publications for this product
Publishing research using ab120409? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"