Recombinant Human DYRK1A protein (ab114522)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      NQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFS ANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVAS
    • 分子量
      36 kDa including tags
    • 領域
      674 to 763

特性

Our Abpromise guarantee covers the use of ab114522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • Dual specificity tyrosine phosphorylation regulated kinase
    • Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A
    • Dual specificity tyrosine phosphorylation regulated kinase 1
    • Dual specificity tyrosine phosphorylation regulated kinase 1A
    • Dual specificity tyrosine-phosphorylation-regulated kinase 1A
    • Dual specificity YAK 1 related kinase
    • Dual specificity YAK1 related kinase
    • Dual specificity YAK1-related kinase
    • DYR1A_HUMAN
    • DYRK
    • DYRK 1
    • DYRK 1A
    • DYRK1
    • Dyrk1a
    • DYRKA
    • hMNB
    • HP 86
    • HP86
    • Minibrain (Drosophila) homolog
    • Minibrain homolog
    • Minibrain, Drosophila, homolog of
    • MNB
    • MNB protein kinase
    • Mnb protein kinase homolog hp86
    • MNB protein kinase, Serine/threonine-specific
    • MNB/DYRK protein kinase
    • MNBH
    • MRD7
    • OTTHUMP00000109090
    • OTTHUMP00000109091
    • OTTHUMP00000109094
    • OTTHUMP00000174799
    • Protein kinase minibrain homolog
    • Serine/threonine kinase MNB
    see all
  • 機能
    May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
  • 組織特異性
    Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
  • 関連疾患
    Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
  • 配列類似性
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
    Contains 1 protein kinase domain.
  • 発生段階
    Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain.
  • ドメイン
    The polyhistidine repeats act as targeting signals to nuclear speckles (PubMed:19266028).
  • 翻訳後修飾
    Autophosphorylated on tyrosine residues.
  • 細胞内局在
    Nucleus speckle.
  • Information by UniProt

Recombinant Human DYRK1A protein 画像

  • 12.5% SDS-PAGE analysis of Human DYRK1A protein (ab114522). Stained with Coomassie Blue.

Recombinant Human DYRK1A protein (ab114522) 使用論文

ab114522 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

I can confirm the protein ab114522 is exactly the immunising peptide for ab54944 and could therefore serve as a positive control.

I hope this information was helpful. Please do not hesitate to contact us...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録