(R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), MAO-B selective inhibitor (ab120604)
Key features and details
- MAO-B selective inhibitor
- CAS Number: 14611-52-0
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
-
製品名
(R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), MAO-B selective inhibitor -
製品の詳細
MAO-B selective inhibitor -
別名
- Selegiline hydrochloride
-
生理活性の詳細
Selective and irreversible MAO-B inhibitor (IC50 = 6.8 nM). Elicits neuroprotective and neuronal rescue activity. Alleviates oxidative stress.
-
精製度
> 99% -
CAS 番号
14611-52-0 -
構造式
製品の特性
-
体系名
(R)-(-)-N-α-Dimethyl-N-2-propynylbenzeneethanamine hydrochloride -
分子量
223.74 -
分子式
C13H17N.HCl -
PubChem 登録番号
26758 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES 線形表記
C[C@H](CC1=CC=CC=C1)N(C)CC#C.Cl -
由来
Synthetic
-
研究分野
画像
-
2D chemical structure image of ab120604, (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), MAO-B selective inhibitor
-
ab692 staining Bcl2 in SK-N-SH cells treated with (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride) (ab120604), by ICC/IF. Increase of Bcl2 expression correlates with increased concentration of (R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride), as described in literature.
The cells were incubated at 37°C for 3h in media containing different concentrations of ab120604 ((R)-(-)-Deprenyl hydrochloride (Selegiline hydrochloride)) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab692 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab120604 は 3 報の論文で使用されています。
- Wang D et al. Novel C7-Substituted Coumarins as Selective Monoamine Oxidase Inhibitors: Discovery, Synthesis and Theoretical Simulation. Molecules 24:N/A (2019). PubMed: 31694262
- Zhang J et al. Mechanisms of the active components from Korean pine nut preventing and treating d-galactose-induced aging rats. Biomed Pharmacother 103:680-690 (2018). PubMed: 29679909
- Nicholatos JW et al. Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6. Acta Neuropathol Commun 6:120 (2018). PubMed: 30409187