(R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT), 5-HT1A receptor agonist (ab120507)
Key features and details
- Selective full 5-HT1A receptor agonist
- CAS Number: 78095-19-9
- Soluble in water to 20 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
(R)-(+)-8-Hydroxy-DPAT hydrobromide (8-Hydroxy DPAT), 5-HT1A receptor agonist -
製品の詳細
Selective full 5-HT1A receptor agonist -
別名
- 8-Hydroxy DPAT
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生理活性の詳細
Selective full 5-HT1A receptor agonist. More active enantiomer of 8-OH-DPAT. Displays greater efficacy at 5-HT1A. Also displays moderate affinity at 5-HT7. Inhibits amphetamine induced dopamine release.
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CAS 番号
78095-19-9 -
構造式
製品の特性
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体系名
(2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide -
分子量
328.29 -
分子式
C16H25NO.HBr -
PubChem 登録番号
11957570 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 20 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CCCN(CCC)[C@@H]1CCC2=C(C1)C(=CC=C2)O.Br -
由来
Synthetic
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研究分野
関連製品
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プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120507 は 1 報の論文で使用されています。
- Qian YW et al. HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability. J Biol Chem 291:22977-22987 (2016). PubMed: 27605665