QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker (ab120117)
Key features and details
- Na+ channel blocker
- CAS Number: 21306-56-9
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker -
製品の詳細
Na+ channel blocker -
別名
- N-Ethyllidocaine bromide
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生理活性の詳細
A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly.
Also available in simple stock solutions (ab144492) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS 番号
21306-56-9 -
構造式
製品の特性
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体系名
N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide -
分子量
343.31 -
分子式
C16H27BrN2O -
PubChem 登録番号
9884487 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
[Br-].O=C(Nc1c(C)cccc1C)C[N+](CC)(CC)CC -
由来
Synthetic
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (13)
ab120117 は 13 報の論文で使用されています。
- Tønnesen J et al. Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue. Cell 172:1108-1121.e15 (2018). PubMed: 29474910
- Chu HY et al. Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons. Neuron 95:1306-1318.e5 (2017). PubMed: 28910619
- Hsu TT et al. Differential Recruitment of Dentate Gyrus Interneuron Types by Commissural Versus Perforant Pathways. Cereb Cortex 26:2715-27 (2016). PubMed: 26045570
- Zonouzi M et al. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nat Neurosci 18:674-82 (2015). PubMed: 25821912
- Soiza-Reilly M et al. Presynaptic gating of excitation in the dorsal raphe nucleus by GABA. Proc Natl Acad Sci U S A 110:15800-5 (2013). PubMed: 24019494