Q-DEVD-OPh, caspase-3 inhibitor (ab142037)
Key features and details
- Potent, irreversible, cell-permeable caspase-3 inhibitor
- CAS Number:
- Purity: > 90%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Q-DEVD-OPh, caspase-3 inhibitor -
製品の詳細
Potent, irreversible, cell-permeable caspase-3 inhibitor -
生理活性の詳細
Potent, irreversible, cell-permeable caspase-3 inhibitor -
精製度
> 90% -
特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 1175 Caspase-3 Inhibitor Q-DEVD-OPh. 1175-5 is the same size as the 5 mg size of ab142037.
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構造式
製品の特性
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分子量
799.77 -
分子式
C38H43F2N5O12 -
配列
DEVD (Modifications: N-terminal quinolyl; C-terminal OPh; Asp-1 = Asp(OMe); Glu-2 = Glu(OMe); Asp-4 = Asp(OMe)) -
PubChem 登録番号
44135278 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(C)C(C(=O)NC(CC(=O)OC)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)C2=NC3=CC=CC=C3C=C2 -
由来
Synthetic
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研究分野
関連製品
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Related Products
画像
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2D chemical structure image of ab142037, Q-DEVD-OPh, caspase-3 inhibitor
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Titration of the Caspase 3 specific inhibitor Q-DEVD-OPh (ab142037) (duplicates; +/- SD).
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab142037 は 1 報の論文で使用されています。
- Zhou XY et al. Inhibition of autophagy blocks cathepsins-tBid-mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes. Cell Death Dis 8:e2618 (2017). PubMed: 28206988