Procainamide hydrochloride, Sodium channel blocker (ab120955)
Key features and details
- Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor.
- CAS Number: 614-39-1
- Purity: > 99%
- Soluble in water to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Procainamide hydrochloride, Sodium channel blocker -
製品の詳細
Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor. -
生理活性の詳細
Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor (Ki = 7.2 μM). Antiarrhythmic in vivo. Limited ability to cross the blood-brain barrier.
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精製度
> 99% -
CAS 番号
614-39-1 -
構造式
製品の特性
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体系名
4-Amino-N-(2-diethylaminoethyl)benzamide hydrochloride -
分子量
271.79 -
分子式
C13H21N3O.HCl -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM and in ethanol to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (5)
ab120955 は 5 報の論文で使用されています。
- Willis JR et al. Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors. Immunity 55:2149-2167.e9 (2022). PubMed: 36179689
- Derking R et al. Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike. Cell Rep 35:108933 (2021). PubMed: 33826885
- Seabright GE et al. Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions. Structure 28:897-909.e6 (2020). PubMed: 32433992
- Struwe WB et al. Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen. Cell Rep 24:1958-1966.e5 (2018). PubMed: 30134158
- Hasan SS et al. Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization. Cell Rep 25:3136-3147.e5 (2018). PubMed: 30540945