Pitstop® 2 - negative control, Negative control for clathrin inhibitor Pitstop® 2 (ab120688)
Key features and details
- Negative control for clathrin inhibitor Pitstop® 2 (ab120687)
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Pitstop® 2 - negative control, Negative control for clathrin inhibitor Pitstop® 2 -
製品の詳細
Negative control for clathrin inhibitor Pitstop® 2 (ab120687) -
生理活性の詳細
Negative control for clathrin inhibitor Pitstop® 2 (ab120687) which is of the same chemical class and has a highly related structure to Pitstop® 2. Inhibits amphiphysin binding to the clathrin TD with an IC50 >100 μM and does not block receptor-mediated endocytosis at concentrations of up to 300 μM (unpublished reports).
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特記事項
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pitstop® is a trademark of Freie Universitat Berlin, Newcastle Innovation Ltd. and Children's Medical Research Institute -
構造式
製品の特性
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体系名
5-(4-Bromobenzylidene)-2-(naphthalen-1-ylamino)-1,3-thiazol-4(5H)-one -
分子量
409.30 -
分子式
C20H13BrN2OS -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (15)
ab120688 は 15 報の論文で使用されています。
- Králová J et al. Sterolight as imaging tool to study sterol uptake, trafficking and efflux in living cells. Sci Rep 12:6264 (2022). PubMed: 35428843
- Abu Rass R et al. Mapping of Tilapia Lake Virus entry pathways with inhibitors reveals dependence on dynamin activity and cholesterol but not endosomal acidification. Front Cell Dev Biol 10:1075364 (2022). PubMed: 36605723
- Abdul-Salam VB et al. CLIC4/Arf6 Pathway. Circ Res 124:52-65 (2019). PubMed: 30582444
- Martínez-Muñoz L et al. Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function. Mol Cell 70:106-119.e10 (2018). PubMed: 29625032
- Albecka A et al. HSV-1 Glycoproteins Are Delivered to Virus Assembly Sites Through Dynamin-Dependent Endocytosis. Traffic 17:21-39 (2016). PubMed: 26459807