Anti-PXR 抗体 (ab118336)
Key features and details
- Mouse polyclonal to PXR
- Suitable for: WB, ICC/IF
- Reacts with: Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-PXR antibody
PXR 一次抗体 製品一覧 -
製品の詳細
Mouse polyclonal to PXR -
由来種
Mouse -
アプリケーション
適用あり: WB, ICC/IFmore details -
種交差性
交差種: Rat, Human -
免疫原
Recombinant full length protein, corresponding to amino acids 1-434 of Human PXR (NP_003880.3).
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ポジティブ・コントロール
- Rat liver tissue lysate; PXR transfected 293T cell line lysate; HepG2 cells.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.4
Constituent: 99% PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab118336の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa.
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ICC/IF |
Use a concentration of 10 µg/ml.
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特記事項 |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa. |
ICC/IF
Use a concentration of 10 µg/ml. |
ターゲット情報
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機能
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. -
組織特異性
Expressed in liver, colon and small intestine. -
配列類似性
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 8856 Human
- Entrez Gene: 84385 Rat
- Omim: 603065 Human
- SwissProt: O75469 Human
- SwissProt: Q9R1A7 Rat
- Unigene: 7303 Human
- Unigene: 207164 Rat
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別名
- BXR antibody
- Nr1i2 antibody
- NR1I2_HUMAN antibody
see all
画像
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Anti-PXR antibody (ab118336) at 1 µg/ml + Rat liver tissue lysate at 50 µg
Developed using the ECL technique.
Predicted band size: 50 kDa -
All lanes : Anti-PXR antibody (ab118336) at 1 µg/ml
Lane 1 : PXR transfected 293T cell line lysate
Lane 2 : Non-transfected 293T cell line lysate
Lysates/proteins at 25 µg per lane.
Developed using the ECL technique.
Predicted band size: 50 kDa -
ab118336 at 10 µg/ml dilution staining PXR in HepG2 cells by Immunofluorescence.
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (3)
ab118336 は 3 報の論文で使用されています。
- Ortiz-Flores M et al. PXR is a target of (-)-epicatechin in skeletal muscle. Heliyon 6:e05357 (2020). PubMed: 33163657
- Jang M et al. Study of melatonin-mediated effects on various hepatic inflammatory responses stimulated by IL-6 in a new HepG2-on-a-chip platform. Biomed Microdevices 20:54 (2018). PubMed: 29946898
- Jing W et al. Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms. J Pharmacol Exp Ther 366:332-340 (2018). PubMed: 29891588