Anti-PTHLH 抗体 (ab125700)
Key features and details
- Rabbit polyclonal to PTHLH
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-PTHLH antibody
PTHLH 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PTHLH -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Rabbit, Cow, Dog, Pig -
免疫原
Recombinant fragment containing a sequence corresponding to a region within amino acids 1-127 of Human PTHLH.(Uniprot: P12272)
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ポジティブ・コントロール
- A549 cell lysate, HepG2 whole cell lysate (ab7900) and HTC116 cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab125700の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 20 kDa.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 20 kDa. |
ターゲット情報
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機能
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
Osteostatin is a potent inhibitor of osteoclastic bone resorption. -
組織特異性
Ubiquitous. Also expressed in the mammary gland. -
関連疾患
Brachydactyly E2 -
配列類似性
Belongs to the parathyroid hormone family. -
翻訳後修飾
There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. -
細胞内局在
Cytoplasm. Nucleus. Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 286767 Cow
- Entrez Gene: 403987 Dog
- Entrez Gene: 5744 Human
- Entrez Gene: 19227 Mouse
- Entrez Gene: 396951 Pig
- Entrez Gene: 24695 Rat
- Omim: 168470 Human
- SwissProt: P58073 Cow
see all -
別名
- HHM antibody
- MGC14611 antibody
- Osteostatin antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab125700 は 4 報の論文で使用されています。
- Dou P et al. Downregulation of microRNA-29b by DNMT3B decelerates chondrocyte apoptosis and the progression of osteoarthritis via PTHLH/CDK4/RUNX2 axis. Aging (Albany NY) 13:7676-7690 (2020). PubMed: 33177241
- Bai M et al. miR-182-5p overexpression inhibits chondrogenesis by down-regulating PTHLH. Cell Biol Int 43:222-232 (2019). PubMed: 30095215
- Duan Z & Lu J Involvement of Aryl Hydrocarbon Receptor in L-Kynurenine-Mediated Parathyroid Hormone-Related Peptide Expression. Horm Cancer N/A:N/A (2019). PubMed: 30689168
- Cao X et al. miR-195 contributes to human osteoarthritis via targeting PTHrP. J Bone Miner Metab N/A:N/A (2018). PubMed: 30465089