Anti-APP-1 抗体 (ab101492)
Key features and details
- Rabbit polyclonal to APP-1
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-APP-1 antibody
APP-1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to APP-1 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Mouse, Human
交差が予測される動物種: Rat, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus -
免疫原
Synthetic peptide corresponding to Human APP-1 aa 525-575 (internal sequence).
Database link: NP_003810.1 -
ポジティブ・コントロール
- Human Bladder Cell Carcinoma, Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma and Prostate Carcinoma. Mouse Teratoma.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab101492の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/100 - 1/500. Antigen retrieval is recommended.
Antigen retrieval with citrate buffer will enhance staining.
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特記事項 |
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IHC-P
1/100 - 1/500. Antigen retrieval is recommended. Antigen retrieval with citrate buffer will enhance staining. |
ターゲット情報
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機能
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. -
組織特異性
Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated. -
配列類似性
Belongs to the polyadenylate-binding protein type-1 family.
Contains 1 PABC domain.
Contains 4 RRM (RNA recognition motif) domains. -
翻訳後修飾
Arg-518 is dimethylated, probably to asymmetric dimethylarginine. -
細胞内局在
Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. - Information by UniProt
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参照データベース
- Entrez Gene: 8761 Human
- Entrez Gene: 230721 Mouse
- Entrez Gene: 298510 Rat
- Omim: 603407 Human
- SwissProt: Q13310 Human
- Unigene: 169900 Human
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別名
- Activated platelet protein 1 antibody
- Activated-platelet protein 1 antibody
- APP 1 antibody
see all
画像
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ab101492 at 1/250 dilution staining APP-1 in a Formalin-fixed, paraffin-embedded section of Human ovarian carcinoma by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection utilised DAB.
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ab101492 at 1/250 dilution staining APP-1 in a formalin-fixed, paraffin-embedded section of mouse teratoma by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection utilised DAB.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab101492 は 1 報の論文で使用されています。
- Hartmann H et al. Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity. Life Sci Alliance 1:e201800070 (2018). PubMed: 30456350