ORC2 antibody [3G6] (ab22537)

Product Name 

ORC2 antibody [3G6]

Product type 

Primary antibodies

Description 

Rat monoclonal [3G6] to ORC2

Immunogen 

Full length protein (Human): ORC2 (hsORC)

Reacts with 
(species key)

Hu

Specificity 

ab22537 recognises ORC2

Tested applications 
(see key)

IP, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution (used at 1/5000 for 1 hr incubation see Abreview by Mary Donaldson for further information). Predicted molecular weight: 66 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Nuclear

Research areas 

Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Nuclear Pore Complex
Chromatin and Nuclear Signaling >> DNA / RNA >> DNA Synthesis >> Other

Relevance 

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC2L is a subunit of the ORC complex. ORC2L forms a core complex with ORC3L, 4L, and 5L. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. ORC2L specifically associate with the origin of replication of Epstein Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.

Database links 

Raised in 

Rat

Clonality 

Monoclonal

Clone number 

3G6

Myeloma 

x63-Ag8.653

Isotype 

IgG2a

Purity 

Protein G purified

Storage buffer 

Preservative: 0.1% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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