Anti-Niemann Pick C1 Like 1/NPC1L1 抗体 (ab121000)
Key features and details
- Goat polyclonal to Niemann Pick C1 Like 1/NPC1L1
- Suitable for: WB
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Niemann Pick C1 Like 1/NPC1L1 antibody
Niemann Pick C1 Like 1/NPC1L1 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to Niemann Pick C1 Like 1/NPC1L1This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »
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由来種
Goat -
種交差性
交差が予測される動物種: Mouse, Rat, Rabbit, Human, Cynomolgus monkey, Chinese hamster -
免疫原
Synthetic peptide corresponding to Mouse Niemann Pick C1 Like 1/NPC1L1 aa 50-150 (N terminal).
Database link: NP_997125.2 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 147 kDa.
A 1 hour primary incubation is recommended for this product. Preliminary experiments in Mouse and Rat Liver lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would welcome your feedback if you have tested this antibody in more suitable positive controls. |
特記事項 |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 147 kDa. A 1 hour primary incubation is recommended for this product. Preliminary experiments in Mouse and Rat Liver lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would welcome your feedback if you have tested this antibody in more suitable positive controls. |
ターゲット情報
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機能
Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. -
組織特異性
Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle. -
配列類似性
Belongs to the patched family.
Contains 1 SSD (sterol-sensing) domain. -
翻訳後修飾
Highly glycosylated. -
細胞内局在
Apical cell membrane. Cell membrane. Cytoplasmic vesicle membrane. Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5. - Information by UniProt
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参照データベース
- Entrez Gene: 29881 Human
- Entrez Gene: 237636 Mouse
- Entrez Gene: 432367 Rat
- Omim: 608010 Human
- SwissProt: Q9UHC9 Human
- SwissProt: Q6T3U4 Mouse
- SwissProt: Q6T3U3 Rat
- Unigene: 567486 Human
see all -
別名
- Niemann Pick C1 like protein 1 antibody
- Niemann Pick disease type C1 gene like 1 antibody
- Niemann-Pick C1-like protein 1 antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (2)
ab121000 は 2 報の論文で使用されています。
- Huang WW et al. Cis- and Trans-Palmitoleic Acid Isomers Regulate Cholesterol Metabolism in Different Ways. Front Pharmacol 11:602115 (2020). PubMed: 33363473
- Zhong CY et al. Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice. Sci Rep 5:10512 (2015). WB ; Mouse . PubMed: 26015368