Anti-Nav1.6/SCN8A 抗体 (ab65166)
Key features and details
- Rabbit polyclonal to Nav1.6/SCN8A
- Suitable for: IHC-Fr, IHC-P, IHC-FrFl, IHC-FoFr, ICC/IF, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Nav1.6/SCN8A antibody
Nav1.6/SCN8A 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Nav1.6/SCN8A -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Fr, IHC-P, IHC-FrFl, IHC-FoFr, ICC/IF, WBmore details -
種交差性
交差種: Mouse, Rat, Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab65166の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-Fr |
Use at an assay dependent concentration.
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IHC-P | (1) |
Use at an assay dependent concentration.
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IHC-FrFl | (1) |
Use at an assay dependent concentration.
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IHC-FoFr |
Use at an assay dependent concentration. PubMed: 27905510
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ICC/IF | (1) |
Use at an assay dependent concentration.
See Abreview. |
WB | (1) |
Use at an assay dependent concentration.
|
特記事項 |
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IHC-Fr
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
IHC-FrFl
Use at an assay dependent concentration. |
IHC-FoFr
Use at an assay dependent concentration. PubMed: 27905510 |
ICC/IF
Use at an assay dependent concentration. See Abreview. |
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation. -
組織特異性
Isoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages. -
配列類似性
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.
Contains 1 IQ domain. -
ドメイン
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. -
翻訳後修飾
May be ubiquitinated by NEDD4L; which would promote its endocytosis. -
細胞内局在
Membrane and Cytoplasmic vesicle. Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 6334 Human
- Entrez Gene: 20273 Mouse
- Entrez Gene: 29710 Rat
- Omim: 600702 Human
- SwissProt: Q9UQD0 Human
- SwissProt: Q9WTU3 Mouse
- SwissProt: O88420 Rat
- Unigene: 710638 Human
see all -
別名
- CerIII antibody
- CIAT antibody
- EIEE13 antibody
see all
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (12)
ab65166 は 12 報の論文で使用されています。
- Yang X et al. Social Deficits and Cerebellar Degeneration in Purkinje Cell Scn8a Knockout Mice. Front Mol Neurosci 15:822129 (2022). PubMed: 35557557
- Liu W et al. Altered expression of voltage gated sodium channel Nav1.1 is involved in motor ability in MPTP-treated mice. Brain Res Bull 170:187-198 (2021). PubMed: 33610724
- Okada T et al. Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target. Sci Adv 7:N/A (2021). PubMed: 33741588
- Montero MC et al. Neosaxitoxin Inhibits the Expression of Inflammation Markers of the M1 Phenotype in Macrophages. Mar Drugs 18:N/A (2020). PubMed: 32471037
- Tan YX et al. Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APP/PS1 Mice. Neural Plast 2020:9132720 (2020). PubMed: 32256560