Native Mouse Vitronectin/S-Protein (ab92727)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Suitable for: Functional Studies, SDS-PAGE
製品の詳細
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製品名
Native Mouse Vitronectin/S-Protein
Vitronectin/S-Protein タンパク質・ペプチド 製品一覧 -
精製度
> 95 % SDS-PAGE.
ab92727 was prepared from fresh Mouse plasma using urea as a denaturant. -
発現系
Native -
タンパク質長
Full length protein -
Animal free
No -
由来
Native -
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生物種
Mouse
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特性
Our Abpromise guarantee covers the use of ab92727 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Functional Studies
SDS-PAGE
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製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.40
Constituents: 0.82% Sodium phosphate, 0.58% Sodium chloride
関連情報
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別名
- Complement S Protein
- Epibolin
- S Protein
see all -
機能
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. -
組織特異性
Plasma. -
配列類似性
Contains 4 hemopexin repeats.
Contains 1 SMB (somatomedin-B) domain. -
ドメイン
The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin. -
翻訳後修飾
Sulfated on 2 tyrosine residues.
N- and O-glycosylated.
Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Phosphorylation sites are present in the extracellular medium. -
細胞内局在
Secreted, extracellular space. - Information by UniProt
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プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (4)
ab92727 は 4 報の論文で使用されています。
- Zhang J et al. Discovery of a new class of integrin antibodies for fibrosis. Sci Rep 11:2118 (2021). PubMed: 33483531
- Bae HB et al. Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages. J Immunol 190:2273-81 (2013). Functional Studies . PubMed: 23345331
- Bae HB et al. Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways. Am J Respir Cell Mol Biol 46:790-6 (2012). Functional Studies ; Mouse . PubMed: 22281987
- Zmijewski JW et al. Inhibition of neutrophil apoptosis by PAI-1. Am J Physiol Lung Cell Mol Physiol 301:L247-54 (2011). PubMed: 21622848