Anti-NT5C2 抗体 (ab96084)
Key features and details
- Rabbit polyclonal to NT5C2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-NT5C2 antibody -
製品の詳細
Rabbit polyclonal to NT5C2 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Cow, Zebrafish -
免疫原
Recombinant fragment, containing a sequence corresponding to a region within amino acids 108 and 332 of Human NT5C2.
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ポジティブ・コントロール
- HepG2 whole cell lysate (ab7900) can be used as a positive control in WB. H1299 and HeLaS3 whole cell lysate, OVCA tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab96084の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 65 kDa.
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IHC-P |
1/100 - 1/250.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 65 kDa. |
IHC-P
1/100 - 1/250. |
ターゲット情報
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機能
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. -
配列類似性
Belongs to the 5'(3')-deoxyribonucleotidase family. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 281951 Cow
- Entrez Gene: 22978 Human
- Entrez Gene: 76952 Mouse
- Entrez Gene: 324845 Zebrafish
- Omim: 600417 Human
- SwissProt: O46411 Cow
- SwissProt: P49902 Human
- SwissProt: Q3V1L4 Mouse
see all -
別名
- 5' nucleotidase (purine) cytosolic type B antibody
- 5NTC_HUMAN antibody
- cN II antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab96084 は 4 報の論文で使用されています。
- Fei X et al. TRIM22 orchestrates the proliferation of GBMs and the benefits of TMZ by coordinating the modification and degradation of RIG-I. Mol Ther Oncolytics 26:413-428 (2022). PubMed: 36159777
- Carlini F et al. Different Susceptibility of T and B Cells to Cladribine Depends On Their Levels of Deoxycytidine Kinase Activity Linked to Activation Status. J Neuroimmune Pharmacol N/A:N/A (2021). PubMed: 33851318
- Tzoneva G et al. Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. Nat Med 19:368-71 (2013). WB . PubMed: 23377281
- Meyer JA et al. Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia. Nat Genet 45:290-4 (2013). PubMed: 23377183