Anti-NALP2 抗体 (ab36850)
Key features and details
- Rabbit polyclonal to NALP2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-NALP2 antibody
NALP2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to NALP2 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to 12 amino acids near the carboxy-terminus of human NALP2.
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ポジティブ・コントロール
- PC-3 cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab36850の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 96 kDa (predicted molecular weight: 121 kDa).
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特記事項 |
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WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 96 kDa (predicted molecular weight: 121 kDa). |
ターゲット情報
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機能
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. -
組織特異性
Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. -
配列類似性
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 8 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. -
ドメイン
The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.
When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 55655 Human
- Omim: 609364 Human
- SwissProt: Q9NX02 Human
- Unigene: 369279 Human
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別名
- CLR19.9 antibody
- FLJ20510 antibody
- Leucine rich repeat and PYD containing protein 2 antibody
see all
画像
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Anti-NALP2 antibody (ab36850) at 1 µg/ml + PC-3 cell lysate
Predicted band size: 121 kDa
Observed band size: 96 kDa why is the actual band size different from the predicted?
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab36850 は 2 報の論文で使用されています。
- Brand FJ et al. Acidification changes affect the inflammasome in human nucleus pulposus cells. J Inflamm (Lond) 13:29 (2016). Human . PubMed: 27563282
- Ji S et al. Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. Infect Immun 77:1044-52 (2009). WB ; Human . PubMed: 19103770