Anti-MVP 抗体 [1032] - BSA and Azide free (ab213122)
Key features and details
- Mouse monoclonal [1032] to MVP - BSA and Azide free
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-MVP antibody [1032] - BSA and Azide free
MVP 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [1032] to MVP - BSA and Azide free -
由来種
Mouse -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus corresponding to Human MVP. (Proteins precipitated from Human breast cancer MCF7 cells).
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ポジティブ・コントロール
- Human testicular carcinoma and breast carcinoma tissues; MCF7 and HeLa cells.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.2
Constituent: 100% PBS -
キャリア・フリー
はい -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
ab213122 was purified from bioreactor concentrate by Protein A/G. -
ポリ/モノ
モノクローナル -
クローン名
1032 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
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Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab213122の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
(Primary incubation for 30 minutes at RT). |
特記事項 |
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IHC-P
Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. (Primary incubation for 30 minutes at RT). |
ターゲット情報
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機能
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. -
組織特異性
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. -
配列類似性
Contains 9 MVP (vault) repeats. -
ドメイン
MVP 3 mediates interaction with PTEN.
MVP 4 mediates interaction with PARP4. -
翻訳後修飾
Phosphorylated on Tyr residues after EGF stimulation.
Dephosphorylated by PTPN11. -
細胞内局在
Cytoplasm. Nucleus > nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment. - Information by UniProt
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参照データベース
- Entrez Gene: 9961 Human
- Omim: 605088 Human
- SwissProt: Q14764 Human
- Unigene: 632177 Human
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別名
- LRP antibody
- Lung resistance related protein antibody
- Lung resistance-related protein antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (0)
ab213122 は論文での使用が確認できていません。