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Product Name
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MRP2 antibody
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MRP2 抗体 (5件) 一覧
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to MRP2
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Immunogen
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Synthetic peptide corresponding to C-terminal residues of mouse MRP2.
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Reacts with
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Ms
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Tested applications
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ELISA, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution.
WB: Use at a concentration of 1 µg/ml for 2hrs. Predicted molecular weight: 174 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; multi pass membrane protein.
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Research areas
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Cancer >> Drug resistance >> MRP-related proteins
Signal Transduction >> Metabolism >> Plasma Membrane >> Channels
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Relevance
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MRP2 mediates hepatobiliary excretion of numerous organic anions and may function as a cellular cisplatin transporter. The highest expression is found in liver. MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. Defects in MRP2 are the cause of Dubin-Johnson syndrome, an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
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MRP2 antibody (ab58709)の別名 |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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Search PubMed (MEDLINE) for references to MRP2
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MRP2 antibody - more information
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Customer reviews (feedback) regarding MRP2 antibody |
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