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Product Name
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MRP2 antibody [M2I-4]
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MRP2 抗体 (5件) 一覧
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [M2I-4] to MRP2
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Immunogen
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Bacterial fusion protein of human MRP 2 containing amino acids of 215-310.
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Reacts with
(species key)
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Hu
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Specificity
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ab3372 does not cross-react with the human MDR1, MRP1, MRP3 or MRP5 gene products.
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Epitope
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This antibody reacts with an internal epitope of MRP 2.
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Tested applications
(see key)
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ICC, IHC-Fr, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Optimal dilutions / concentrations should be determined by the end user.
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Cellular localization
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Membrane; multi pass membrane protein.
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Research areas
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Cancer >> Drug resistance >> MRP-related proteins
Signal Transduction >> Metabolism >> Plasma Membrane >> Channels
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Relevance
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MRP2 mediates hepatobiliary excretion of numerous organic anions and may function as a cellular cisplatin transporter. The highest expression is found in liver. MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. Defects in MRP2 are the cause of Dubin-Johnson syndrome, an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
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MRP2 antibody [M2I-4] (ab3372)の別名 |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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M2I-4
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Isotype
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IgG
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Storage buffer
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PBS with 1% BSA and 0.1% sodium azide Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Storage instructions
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Store at +4°C.
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Abcam では全ての製品情報を一元管理しており、 MRP2 antibody [M2I-4] について私たちが知りうる全ての情報がこのデータシートでご覧いただけます。ご不明な点がありましたら、 お問い合わせください。 |
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References for MRP2 antibody [M2I-4] (ab3372)
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This product has been used in:
Janneh O et al. Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP. AIDS 19:2097-102 (2005). PubMed: 16284458
If you publish research using ab3372 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to MRP2
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MRP2 antibody [M2I-4] - more information
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Customer reviews (feedback) regarding MRP2 antibody [M2I-4] |
Customer FAQs regarding MRP2 antibody [M2I-4] |
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Contact Abcam with a Technical Enquiry about MRP2 antibody [M2I-4] |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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