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Products:Signal Transduction >> Metabolism >> Plasma Membrane >> Channels
Overview
Product name
Anti-MRP2 antibody [M2I-4]
MRP2 抗体 (6件) 一覧
Description
Mouse monoclonal [M2I-4] to MRP2
Specificity
ab3372 does not cross-react with the human MDR1, MRP1, MRP3 or MRP5 gene products.
Tested applications
IHC-P, IP, ICC, IHC-Fr, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Bacterial fusion protein of human MRP 2 containing amino acids of 215-310.
Epitope
This antibody reacts with an internal epitope of MRP 2.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
PBS with 1% BSA and 0.1% sodium azide
Concentration
Concentration information loading...
Clonality
Monoclonal
Clone number
M2I-4
Isotype
IgG
Research areas
Cancer >> Drug resistance >> MRP-related proteins
Signal Transduction >> Metabolism >> Plasma Membrane >> Channels
Applications
Show applications key
Our Abpromise guarantee covers the use of ab3372 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P
IHC-P: 1/20IHC-P: 1/20
IP: Use at an assay dependent concentration. (PubMed: 17156953)
ICC: Use at an assay dependent concentration.
IHC-Fr: Use at an assay dependent concentration.
WB: Use at an assay dependent concentration.
Target
Function
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Tissue specificity
Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Involvement in disease
Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
Sequence similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ92887
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ABC30 antibody
- ABCC2 antibody
- ATP binding cassette sub family C (CFTR/MRP) member 2 antibody
see all
Database links
- Entrez Gene: 1244 Human
- Omim: 601107 Human
- SwissProt: Q92887 Human
- Unigene: 193852 Human
- Unigene: 368243 Human
References for Anti-MRP2 antibody [M2I-4] (ab3372)
This product has been referenced in:
- Karla PKet al. Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux. Int J Pharm 336:12-21 (2007). IP; Human.Read more (PubMed: 17156953) »
- Janneh Oet al. Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP. AIDS 19:2097-102 (2005).Read more (PubMed: 16284458) »
See all 2 publications for this product
Publishing research using ab3372? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"