Anti-MPRA 抗体 (ab75508)
Key features and details
- Rabbit polyclonal to MPRA
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-MPRA antibody -
製品の詳細
Rabbit polyclonal to MPRA -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ・コントロール
- Extracts from 293 and COLO cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg2+ and Ca2+ -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab75508の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 40 kDa.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 40 kDa. |
ターゲット情報
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関連性
MPRA belongs to the ADIPOR family. It is a steroid membrane receptor which binds progesterone in vitro. MPRA may be involved in oocyte maturation. It is expressed in ovary, testis, placenta, uterus and bladder -
細胞内局在
Membrane; Multi pass membrane protein -
参照データベース
- Entrez Gene: 164091 Human
- Omim: 607779 Human
- SwissProt: Q86WK9 Human
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別名
- Membrane progestin receptor alpha antibody
- mPR alpha antibody
- MRPA antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (7)
ab75508 は 7 報の論文で使用されています。
- Sztachelska M et al. Functional Implications of Estrogen and Progesterone Receptors Expression in Adenomyosis, Potential Targets for Endocrinological Therapy. J Clin Med 11:N/A (2022). PubMed: 35956024
- Zhang J et al. Rapamycin Antagonizes BCRP-Mediated Drug Resistance Through the PI3K/Akt/mTOR Signaling Pathway in mPRa-Positive Breast Cancer. Front Oncol 11:608570 (2021). PubMed: 33912444
- Lozovyy V et al. Progesterone receptor membrane components: key regulators of fetal membrane integrity. Biol Reprod 104:445-456 (2021). PubMed: 33048113
- Ponikwicka-Tyszko D et al. Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice. Cancers (Basel) 12:N/A (2020). PubMed: 33158280
- Ponikwicka-Tyszko D et al. Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression. EBioMedicine 47:170-183 (2019). PubMed: 31466918
- Zhou L et al. Progesterone suppresses triple-negative breast cancer growth and metastasis to the brain via membrane progesterone receptor a. Int J Mol Med 40:755-761 (2017). PubMed: 28713912
- Bashour NM & Wray S Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone receptor membrane component 1. Endocrinology 153:4457-69 (2012). PubMed: 22822163