Anti-MAML1 抗体 (ab17019)
Key features and details
- Goat polyclonal to MAML1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-MAML1 antibody
MAML1 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to MAML1 -
由来種
Goat -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Synthetic peptide:
VLPTCPMAEFALPR
, corresponding to N terminal amino acids 2-15 of Human MAML1(Peptide available as ab23302.) -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab17019の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 108 kDa.
1 hour primary incubation is recommended for this product. |
特記事項 |
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WB
Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 108 kDa. 1 hour primary incubation is recommended for this product. |
ターゲット情報
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機能
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. -
組織特異性
Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. -
配列類似性
Belongs to the mastermind family. -
ドメイン
The C-terminal region is required for transcriptional activation. -
細胞内局在
Nucleus speckle. Nuclear, in a punctate manner. - Information by UniProt
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参照データベース
- Entrez Gene: 9794 Human
- Entrez Gene: 103806 Mouse
- Omim: 605424 Human
- SwissProt: Q92585 Human
- SwissProt: Q6T264 Mouse
- Unigene: 631951 Human
- Unigene: 51116 Mouse
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別名
- Mam-1 antibody
- Mam1 antibody
- MAML 1 antibody
see all
画像
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (2)
ab17019 は 2 報の論文で使用されています。
- Kaur R et al. Heterogeneous Ribonucleoprotein A1 (hnRNPA1) Interacts with the Nucleoprotein of the Influenza a Virus and Impedes Virus Replication. Viruses 14:N/A (2022). PubMed: 35215793
- Wu X et al. Crosstalk between BMP and Notch Induces Sox2 in Cerebral Endothelial Cells. Cells 8:N/A (2019). PubMed: 31174355