Anti-MAL2 抗体 (ab75347)
Key features and details
- Rabbit polyclonal to MAL2
- Suitable for: ELISA, ICC, WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-MAL2 antibody
MAL2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to MAL2 -
由来種
Rabbit -
アプリケーション
適用あり: ELISA, ICC, WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Synthetic peptide derived from the N-terminal domain of human MAL2
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab75347の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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ICC |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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特記事項 |
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ELISA
Use at an assay dependent concentration. |
ICC
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. -
組織特異性
Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine. -
配列類似性
Belongs to the MAL family.
Contains 1 MARVEL domain. -
細胞内局在
Cell membrane. Apical cell membrane. Endomembrane system. Cytoplasm > perinuclear region. Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma HepG2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized HepG2 cells, distributed to the perinuclear region. - Information by UniProt
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参照データベース
- Entrez Gene: 114569 Human
- Entrez Gene: 105853 Mouse
- Entrez Gene: 362911 Rat
- Omim: 609684 Human
- SwissProt: Q969L2 Human
- SwissProt: Q8BI08 Mouse
- Unigene: 201083 Human
- Unigene: 410994 Mouse
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別名
- MAL 2 antibody
- MAL proteolipid protein 2 antibody
- Mal, T cell differentiation protein 2 antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (8)
ab75347 は 8 報の論文で使用されています。
- Rodriguez E et al. Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits. Commun Biol 5:41 (2022). PubMed: 35017635
- Yuan J et al. Multi-Omics Analysis of the Therapeutic Value of MAL2 Based on Data Mining in Human Cancers. Front Cell Dev Biol 9:736649 (2021). PubMed: 35111745
- Tao L et al. FTO modifies the m6A level of MALAT and promotes bladder cancer progression. Clin Transl Med 11:e310 (2021). PubMed: 33634966
- Zhang B et al. MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation. Biochem Biophys Res Commun 554:63-70 (2021). PubMed: 33780861
- López-Coral A et al. MAL2-Induced Actin-Based Protrusion Formation is Anti-Oncogenic in Hepatocellular Carcinoma. Cancers (Basel) 12:N/A (2020). PubMed: 32059473
- Lamm KYB et al. Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome. Elife 7:N/A (2018). PubMed: 29309034
- Li J et al. The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis. PLoS One 12:e0178515 (2017). IHC-P ; Human . PubMed: 28562687
- Katz E et al. An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer. PLoS One 6:e17083 (2011). WB . PubMed: 21347235