PE Anti-M6PR (cation independent) 抗体 [MEM-238] (ab77135)
Key features and details
- PE Mouse monoclonal [MEM-238] to M6PR (cation independent)
- Suitable for: Flow Cyt (Intra), Flow Cyt
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG1
Related conjugates and formulations
製品の概要
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製品名
PE Anti-M6PR (cation independent) antibody [MEM-238]
M6PR (cation independent) 一次抗体 製品一覧 -
製品の詳細
PE Mouse monoclonal [MEM-238] to M6PR (cation independent) -
由来種
Mouse -
標識
PE. Ex: 488nm, Em: 575nm -
アプリケーション
適用あり: Flow Cyt (Intra), Flow Cytmore details -
種交差性
交差種: Human
交差が予測される動物種: Non human primates -
免疫原
Tissue, cells or virus corresponding to Human M6PR (cation independent).
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エピトープ
Ab77135 recognizes an epitope between domains 2 and 5 of CD222 -
ポジティブ・コントロール
- Flow Cyt: Human blood cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 0.2% BSA, 0.2% PBS
0.2% BSA (high-grade protease free) -
Concentration information loading...
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精製度
Size exclusion -
特記事項(精製)
Purity >95% by SDS-PAGE. -
ポリ/モノ
モノクローナル -
クローン名
MEM-238 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab77135の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Flow Cyt (Intra) |
Use at an assay dependent concentration.
Use 20 ul for 10^6 cells in a suspension or 100 ul of whole blood. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
|
Flow Cyt |
Use at an assay dependent concentration.
|
特記事項 |
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Flow Cyt (Intra)
Use at an assay dependent concentration. Use 20 ul for 10^6 cells in a suspension or 100 ul of whole blood. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Flow Cyt
Use at an assay dependent concentration. |
ターゲット情報
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機能
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. -
配列類似性
Belongs to the MRL1/IGF2R family.
Contains 1 fibronectin type-II domain. -
ドメイン
Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends. -
細胞内局在
Lysosome membrane. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface. - Information by UniProt
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参照データベース
- Entrez Gene: 3482 Human
- Omim: 147280 Human
- SwissProt: P11717 Human
- Unigene: 487062 Human
- Unigene: 673278 Human
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別名
- 300 kDa mannose 6 phosphate receptor antibody
- 300 kDa mannose 6-phosphate receptor antibody
- Cation independent mannose 6 phosphate receptor antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab77135 は 1 報の論文で使用されています。
- Leksa V et al. The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration. J Biol Chem 277:40575-82 (2002). PubMed: 12189157