Anti-LTBP2 抗体 (ab121193)
Key features and details
- Rabbit polyclonal to LTBP2
- Suitable for: ICC, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-LTBP2 antibody -
製品の詳細
Rabbit polyclonal to LTBP2 -
由来種
Rabbit -
アプリケーション
適用あり: ICC, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
antigen sequence, corresponding to internal sequence amino acids 241-376 of Human LTBP2.
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ポジティブ・コントロール
- IHC-P: Human lung tissue; ICC: U-2 OS cells.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab121193の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC |
Use a concentration of 0.25 - 2 µg/ml.
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IHC-P |
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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特記事項 |
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ICC
Use a concentration of 0.25 - 2 µg/ml. |
IHC-P
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
May play an integral structural role in elastic-fiber architectural organization and/or assembly. -
組織特異性
Expressed in lung, weakly expressed in heart, placenta, liver and skeletal muscle. -
関連疾患
Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D) [MIM:613086]. An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
Defects in LTBP2 are the cause of microspherophakia (MCSPH) [MIM:251750]. It is a rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation. -
配列類似性
Belongs to the LTBP family.
Contains 20 EGF-like domains.
Contains 4 TB (TGF-beta binding) domains. -
ドメイン
Associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. -
翻訳後修飾
Contains hydroxylated asparagine residues. -
細胞内局在
Secreted. Localized in nuchal ligament and aorta to the fibrillin-containing, microfibrillar component of elastic fibers. - Information by UniProt
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参照データベース
- Entrez Gene: 4053 Human
- Omim: 602091 Human
- SwissProt: Q14767 Human
- Unigene: 512776 Human
- Unigene: 597522 Human
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別名
- C14orf141 antibody
- Chromosome 14 open reading frame 141 antibody
- Latent TGF beta binding protein 2 antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling MLTBP2 with ab121193 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
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Immunocytochemistry analysis of U-2 OS (human bone osteosarcoma epithelial cell line) cells labelling MLTBP2 with ab121193 at 2 µg/mL.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (10)
ab121193 は 10 報の論文で使用されています。
- Shi C et al. Latent-transforming growth factor β-binding protein 2 accelerates cardiac fibroblast apoptosis by regulating the expression and activity of caspase-3. Exp Ther Med 22:1146 (2021). PubMed: 34504591
- Langley MR et al. High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system. Biochim Biophys Acta Mol Basis Dis 1866:165630 (2020). PubMed: 31816440
- Chen J et al. Expression and clinical significance of latent-transforming growth factor beta-binding protein 2 in primary hepatocellular carcinoma. Medicine (Baltimore) 98:e17216 (2019). PubMed: 31574831
- Huang Y et al. High Expression of LTBP2 Contributes to Poor Prognosis in Colorectal Cancer Patients and Correlates with the Mesenchymal Colorectal Cancer Subtype. Dis Markers 2019:5231269 (2019). PubMed: 30956730
- Wang J et al. LTBP2 promotes the migration and invasion of gastric cancer cells and predicts poor outcome of patients with gastric cancer. Int J Oncol 52:1886-1898 (2018). PubMed: 29620158
- Wang C et al. Latent Transforming Growth Factor ß Binding Protein 2 (LTBP2) as a Novel Biomarker for the Diagnosis and Prognosis of Pancreatic Carcinoma. Med Sci Monit 23:3232-3239 (2017). IHC-P ; Human . PubMed: 28669978
- Zhou X et al. CACNA1B (Cav2.2) Overexpression and Its Association with Clinicopathologic Characteristics and Unfavorable Prognosis in Non-Small Cell Lung Cancer. Dis Markers 2017:6136401 (2017). PubMed: 28127114
- Han L et al. LTBP2 is a prognostic marker in head and neck squamous cell carcinoma. Oncotarget 7:45052-45059 (2016). PubMed: 27281608
- Yoon H et al. Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system. Biochim Biophys Acta 1862:545-555 (2016). PubMed: 26826016
- Hornigold N & Mooney A Extracellular matrix-induced Hic-5 expression in glomerular mesangial cells leads to a prosclerotic phenotype independent of TGF-ß. FASEB J 29:4956-67 (2015). PubMed: 26405299