Anti-LAMC2 抗体 (ab96327)
Key features and details
- Rabbit polyclonal to LAMC2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-LAMC2 antibody
LAMC2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to LAMC2 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Dog -
免疫原
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 445 and 627 of Human LAMC2
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ポジティブ・コントロール
- Raji whole cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab96327の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 131 kDa.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 131 kDa. |
ターゲット情報
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機能
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. -
組織特異性
The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli. -
関連疾患
Defects in LAMC2 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB) [MIM:226700]; also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. -
配列類似性
Contains 8 laminin EGF-like domains.
Contains 1 laminin IV type A domain. -
ドメイン
The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain IV is globular. -
細胞内局在
Secreted > extracellular space > extracellular matrix > basement membrane. Major component. - Information by UniProt
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参照データベース
- Entrez Gene: 3918 Human
- Entrez Gene: 16782 Mouse
- Entrez Gene: 192362 Rat
- Omim: 150292 Human
- SwissProt: Q13753 Human
- SwissProt: Q61092 Mouse
- Unigene: 591484 Human
- Unigene: 329272 Mouse
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別名
- 3918 antibody
- B2T antibody
- BM600 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (6)
ab96327 は 6 報の論文で使用されています。
- Han DS & Lee EO Sp1 Plays a Key Role in Vasculogenic Mimicry of Human Prostate Cancer Cells. Int J Mol Sci 23:N/A (2022). PubMed: 35163245
- Han DS et al. Resveratrol suppresses serum-induced vasculogenic mimicry through impairing the EphA2/twist-VE-cadherin/AKT pathway in human prostate cancer PC-3 cells. Sci Rep 12:20125 (2022). PubMed: 36418859
- Yeo C et al. Serum promotes vasculogenic mimicry through the EphA2/VE-cadherin/AKT pathway in PC-3 human prostate cancer cells. Life Sci 221:267-273 (2019). PubMed: 30797819
- Ling G et al. Epithelial-mesenchymal transition regulated by p38/MAPK signaling pathways participates in vasculogenic mimicry formation in SHG44 cells transfected with TGF-ß cDNA loaded lentivirus in vitro and in vivo. Int J Oncol 49:2387-2398 (2016). PubMed: 27748800
- Liu X et al. Histone deacetylase 3 expression correlates with vasculogenic mimicry through the phosphoinositide3-kinase / ERK-MMP-laminin5?2 signaling pathway. Cancer Sci 106:857-66 (2015). WB ; Human . PubMed: 25940092
- Wang SY et al. Vasculogenic mimicry and its clinical significance in medulloblastoma. Cancer Biol Ther 13:341-8 (2012). PubMed: 22258034