Anti-KIF7 抗体 (ab95884)
Key features and details
- Rabbit polyclonal to KIF7
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-KIF7 antibody -
製品の詳細
Rabbit polyclonal to KIF7 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Rhesus monkey, Gorilla, Orangutan -
免疫原
Synthetic peptide corresponding to Human KIF7 aa 1200-1300.
Database link: Q2M1P5 -
ポジティブ・コントロール
- HeLa or 293T cell lysate
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特記事項
Shelf Life: 1 year from date of receiptThe Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. The product can be stored for up to 12 months. -
バッファー
pH: 7
Preservative: 0.09% Sodium azide
Constituent: Tris citrate/phosphate -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab95884の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (1) |
1/2000 - 1/10000. Predicted molecular weight: 151 kDa.
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特記事項 |
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WB
1/2000 - 1/10000. Predicted molecular weight: 151 kDa. |
ターゲット情報
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機能
Acts as both a negative and positive regulator of sonic hedgehog (Shh) pathway, acting downstream of SMO. Negatively regulates the pathway by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates the pathway by preventing the processing of the transcription factor GLI3 into its repressor form. Required for efficient localization of GLI3 to cilia in response to Shh. May also act as a ciliary motor. -
組織特異性
Embryonic stem cells, melanotic melanoma and Jurkat T-cells. -
配列類似性
Belongs to the kinesin-like protein family. KIF27 subfamily.
Contains 1 kinesin-motor domain. -
細胞内局在
Cell projection > cilium. SMO is required for its accumulation within cilia. Moves from the cilia base to the cilia tip in response to activation of the Shh pathway. - Information by UniProt
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参照データベース
- Entrez Gene: 374654 Human
- Omim: 611254 Human
- SwissProt: Q2M1P5 Human
- Unigene: 513134 Human
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別名
- EQYK340 antibody
- kif7 antibody
- KIF7_HUMAN antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab95884 は 2 報の論文で使用されています。
- Massa F et al. The deubiquitinating enzyme USP14 controls ciliogenesis and hedgehog signalling. Hum Mol Genet N/A:N/A (2018). PubMed: 30388222
- Ho J et al. Downregulation of the gli transcription factors regulator Kif7 facilitates cell survival and migration of choriocarcinoma cells. PLoS One 9:e108248 (2014). WB ; Human . PubMed: 25265279