Anti-KChIP2 抗体 (ab88542)
Key features and details
- Mouse polyclonal to KChIP2
- Suitable for: WB, ICC/IF
- Reacts with: Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-KChIP2 antibody
KChIP2 一次抗体 製品一覧 -
製品の詳細
Mouse polyclonal to KChIP2 -
由来種
Mouse -
アプリケーション
適用あり: WB, ICC/IFmore details -
種交差性
交差種: Rat, Human -
免疫原
Recombinant full length protein within Human KChIP2. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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ポジティブ・コントロール
- Rat brain lysate with KChIP2 expression, KChIP2 transfected 293T cell lysate and HeLa cell.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab88542の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 31 kDa.
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ICC/IF |
Use a concentration of 10 µg/ml.
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特記事項 |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 31 kDa. |
ICC/IF
Use a concentration of 10 µg/ml. |
ターゲット情報
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機能
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart. -
組織特異性
Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart. -
配列類似性
Belongs to the recoverin family.
Contains 4 EF-hand domains. -
翻訳後修飾
Palmitoylated. Palmitoylation enhances association with the plasma membrane. -
細胞内局在
Cell membrane and Cell membrane. Detected on lipid rafts (By similarity). - Information by UniProt
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参照データベース
- Entrez Gene: 30819 Human
- Entrez Gene: 100911951 Rat
- Entrez Gene: 56817 Rat
- Omim: 604661 Human
- SwissProt: Q9NS61 Human
- SwissProt: Q9JM59 Rat
- Unigene: 97044 Human
- Unigene: 98384 Rat
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製品の状態
There are 9 isoforms produced by alternative splicing. -
別名
- A type potassium channel modulatory protein 2 antibody
- A-type potassium channel modulatory protein 2 antibody
- Cardiac voltage gated potassium channel modulatory subunit antibody
see all
画像
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Anti-KChIP2 antibody (ab88542) at 1 µg/ml + Rat brain lysate with KChIP2 expression at 50 µg
Predicted band size: 31 kDa
Observed band size: 31 kDa -
All lanes : Anti-KChIP2 antibody (ab88542) at 1 µg/ml
Lane 1 : KChIP2 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 50 µg per lane.
Predicted band size: 31 kDa
Observed band size: 31 kDa -
Immunofluorescence of ab88542 on HeLa cell with antibody concentration 10 ug/ml
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (0)
ab88542 は論文での使用が確認できていません。