Anti-Ionotropic Glutamate receptor 2 (phospho S880) 抗体 (ab52180)
Key features and details
- Rabbit polyclonal to Ionotropic Glutamate receptor 2 (phospho S880)
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody
Ionotropic Glutamate receptor 2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Ionotropic Glutamate receptor 2 (phospho S880) -
由来種
Rabbit -
特異性
Detects endogenous levels of Glutamate receptor 2 only when phosphorylated at serine 880. -
アプリケーション
適用あり: IHC-P, WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Synthetic peptide corresponding to Human Ionotropic Glutamate receptor 2 aa 800-900 (phospho S880).
Database link: P42262 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab52180の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
Use at an assay dependent concentration.
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WB |
1/500 - 1/1000. Detects a band of approximately 99 kDa (predicted molecular weight: 99 kDa).
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特記事項 |
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IHC-P
Use at an assay dependent concentration. |
WB
1/500 - 1/1000. Detects a band of approximately 99 kDa (predicted molecular weight: 99 kDa). |
ターゲット情報
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機能
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. -
配列類似性
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily. -
翻訳後修飾
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. -
細胞内局在
Cell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. - Information by UniProt
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参照データベース
- Entrez Gene: 2891 Human
- Entrez Gene: 14800 Mouse
- Omim: 138247 Human
- SwissProt: P42262 Human
- SwissProt: P23819 Mouse
- Unigene: 32763 Human
- Unigene: 220224 Mouse
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別名
- AMPA 2 antibody
- AMPA selective glutamate receptor 2 antibody
- AMPA-selective glutamate receptor 2 antibody
see all
画像
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All lanes : Anti-Ionotropic Glutamate receptor 2 (phospho S880) antibody (ab52180) at 1/500 dilution
Lane 1 : extracts from mouse brain
Lane 2 : extracts from mouse brain with blocking phosphopeptide
Predicted band size: 99 kDa -
Ab52180 at 1/50 dilution staining Human brain tissue, with and without blocking peptide; paraffin embedded.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (17)
ab52180 は 17 報の論文で使用されています。
- Lauretti E et al. Extra virgin olive oil improves synaptic activity, short-term plasticity, memory, and neuropathology in a tauopathy model. Aging Cell 19:e13076 (2020). PubMed: 31762202
- Pensalfini A et al. Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell Rep 33:108420 (2020). PubMed: 33238112
- Khlghatyan J et al. Fxr1 regulates sleep and synaptic homeostasis. EMBO J 39:e103864 (2020). PubMed: 32893934
- Baczyk M et al. Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS. J Exp Med 217:N/A (2020). PubMed: 32484501
- Han K et al. Islet-cell autoantigen 69 mediates the antihyperalgesic effects of electroacupuncture on inflammatory pain by regulating spinal glutamate receptor subunit 2 phosphorylation through protein interacting with C-kinase 1 in mice. Pain 160:712-723 (2019). PubMed: 30699097