Iodotubercidin, adenosine kinase inhibitor (ab120452)
Key features and details
- Potent, adenosine kinase inhibitor
- CAS Number: 24386-93-4
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Iodotubercidin, adenosine kinase inhibitor -
製品の詳細
Potent, adenosine kinase inhibitor -
生理活性の詳細
Potent, specific adenosine kinase inhibitor (IC50 = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).
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CAS 番号
24386-93-4 -
構造式
製品の特性
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体系名
5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine -
分子量
392.15 -
分子式
C11H13IN4O4 -
PubChem 登録番号
46875276 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Nc3ncnc2c3c(I)cn2C1O[C@H](CO)[C@@H](O)[C@H]1O -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120452 は 1 報の論文で使用されています。
- Huang L et al. Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells. PLoS One 9:e98185 (2014). PubMed: 24859235