PE Anti-Integrin beta 4 抗体 [346-11A] (ab216310)
Key features and details
- PE Rat monoclonal [346-11A] to Integrin beta 4
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG2a
製品の概要
-
製品名
PE Anti-Integrin beta 4 antibody [346-11A]
Integrin beta 4 一次抗体 製品一覧 -
製品の詳細
PE Rat monoclonal [346-11A] to Integrin beta 4 -
由来種
Rat -
標識
PE. Ex: 488nm, Em: 575nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Mouse -
免疫原
Other Immunogen Type corresponding to Mouse Integrin beta 4. (Tumor-associated antigen TSP-180 from BALB/c lung carcinoma).
-
ポジティブ・コントロール
- Cell Line I.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. Store In the Dark. -
バッファー
pH: 7.20
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
-
精製度
Protein A purified -
特記事項(精製)
ab216310 was conjugated with Phycoerythrin under optimal conditions. The solution is free of unconjugated Phycoerythrin and unconjugated antibody. -
ポリ/モノ
モノクローナル -
クローン名
346-11A -
アイソタイプ
IgG2a -
軽鎖の種類
kappa -
研究分野
関連製品
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab216310の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Flow Cyt |
Use 0.25µg for 106 cells.
(in 100 µl volume). |
特記事項 |
---|
Flow Cyt
Use 0.25µg for 106 cells. (in 100 µl volume). |
ターゲット情報
-
機能
Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. -
組織特異性
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach. -
関連疾患
Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. -
配列類似性
Belongs to the integrin beta chain family.
Contains 1 Calx-beta domain.
Contains 4 fibronectin type-III domains.
Contains 1 PSI domain.
Contains 1 VWFA domain. -
ドメイン
The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230. -
細胞内局在
Membrane. - Information by UniProt
-
参照データベース
- Entrez Gene: 192897 Mouse
- SwissProt: A2A863 Mouse
- Unigene: 213873 Mouse
-
別名
- CD 104 antibody
- CD104 antibody
- CD104 antigen antibody
see all
画像
データシートおよび資料
-
Datasheet download
参考文献 (1)
ab216310 は 1 報の論文で使用されています。
- Yoshioka T et al. ß4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest 123:682-99 (2013). PubMed: 23348745