IRS1 peptide (ab204862)
Key features and details
- Purity: > 95% HPLC
- Suitable for: Functional Studies, HPLC
製品の詳細
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製品名
IRS1 peptide
IRS1 タンパク質・ペプチド 製品一覧 -
精製度
> 95 % HPLC. -
Animal free
No -
由来
Synthetic -
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配列
KKKSPGEYVNIEFG -
領域
891 to 902
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関連製品
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Recombinant Protein
特性
Our Abpromise guarantee covers the use of ab204862 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Functional Studies
HPLC
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製品の状態
Lyophilized -
備考
ab204862 (IRS1 peptide) can be utilized as a substrate for the following active protein kinases:
ab187246 (Active human ALK protein fragment)
ab84771 (Active human VEGF Receptor 1 full length protein)
ab71657 (Active IGF1 Receptor protein fragment)
ab84791 (Active human Ret protein fragment)
ab125624 (Active human ROS protein fragment) -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
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再構成Dilute peptide in 20mM Tris-HCl, pH 7.5 solution to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.
関連情報
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別名
- HIRS 1
- HIRS1
- Insulin receptor substrate 1
see all -
機能
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. -
関連疾患
Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. -
配列類似性
Contains 1 IRS-type PTB domain.
Contains 1 PH domain. -
翻訳後修飾
Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab204862 は論文での使用が確認できていません。