Anti-IL-23 抗体 [G23-8] (ab91271)
Key features and details
- Rat monoclonal [G23-8] to IL-23
- Suitable for: WB, Functional Studies, ELISA
- Reacts with: Mouse
- Isotype: IgG1
製品の概要
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製品名
Anti-IL-23 antibody [G23-8]
IL-23 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [G23-8] to IL-23 -
由来種
Rat -
特異性
ab91271 reacts with the p19 subunit of IL23. -
アプリケーション
適用あり: WB, Functional Studies, ELISAmore details -
種交差性
交差種: Mouse -
免疫原
Recombinant fragment corresponding to IL-23.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: PBS, 0.87% Sodium chloride -
Concentration information loading...
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精製度
Protein A purified -
特記事項(精製)
ab91271 is affinity purified. -
ポリ/モノ
モノクローナル -
クローン名
G23-8 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab91271の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
Use at an assay dependent concentration.
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Neutralization |
Use at an assay dependent concentration.
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|
Functional Studies |
Use at an assay dependent concentration.
|
|
ELISA |
Use a concentration of 1 - 4 µg/ml.
|
特記事項 |
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WB
Use at an assay dependent concentration. |
Neutralization
Use at an assay dependent concentration. |
Functional Studies
Use at an assay dependent concentration. |
ELISA
Use a concentration of 1 - 4 µg/ml. |
ターゲット情報
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機能
Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. -
組織特異性
Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). -
配列類似性
Belongs to the IL-6 superfamily. -
発生段階
Expressed by newborns dendritic cells. -
細胞内局在
Secreted. Secreted upon association with IL12B. - Information by UniProt
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参照データベース
- Entrez Gene: 16160 Mouse
- Entrez Gene: 83430 Mouse
- SwissProt: P43432 Mouse
- SwissProt: Q9EQ14 Mouse
- Unigene: 125482 Mouse
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別名
- IL 23 A antibody
- IL 23 antibody
- IL 23 subunit alpha antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (1)
ab91271 は 1 報の論文で使用されています。
- Ivanov S et al. Functional relevance of the IL-23-IL-17 axis in lungs in vivo. Am J Respir Cell Mol Biol 36:442-51 (2007). WB . PubMed: 17142310