ICI 118551 hydrochloride, beta2 adrenoceptor antagonist (ab120808)
Key features and details
- Highly selective β2 adrenoceptor antagonist
- CAS Number: 72795-01-8
- Purity: > 99%
- Soluble in water to 10 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
ICI 118551 hydrochloride, beta2 adrenoceptor antagonist -
製品の詳細
Highly selective β2 adrenoceptor antagonist -
生理活性の詳細
Highly selective β2 adrenoceptor antagonist (Ki values are 1.2, 120 and 257 nM at β2, β1 and β3 receptors, respectively). Blood-brain barrier permeable. Decreases vascular tone in vivo.
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精製度
> 99% -
CAS 番号
72795-01-8 -
構造式
製品の特性
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体系名
(2R*,3R*)-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol -
分子量
313.87 -
分子式
C17H27NO2.HCl -
PubChem 登録番号
25102594 -
保存方法
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 10 mM and in DMSO to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC1=C2CCCC2=C(C=C1)OC[C@@H]([C@H](C)NC(C)C)O.Cl -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (5)
ab120808 は 5 報の論文で使用されています。
- Liu Y et al. PlexinA1 activation induced by β2-AR promotes epithelial-mesenchymal transition through JAK-STAT3 signaling in human gastric cancer cells. J Cancer 13:2258-2270 (2022). PubMed: 35517411
- Lan J et al. ß-Adrenoceptors regulate matrix metalloproteinase expression in human urothelial cells under hydrostatic pressure. Neurourol Urodyn 39:1292-1303 (2020). PubMed: 32330364
- Yu H et al. MRGPRX4 is a bile acid receptor for human cholestatic itch. Elife 8:N/A (2019). PubMed: 31500698
- Lai J et al. ß-Adrenoceptor signaling regulates proliferation and contraction of human bladder smooth muscle cells under pathological hydrostatic pressure. J Cell Biochem 120:17872-17886 (2019). PubMed: 31161623
- McMacken G et al. The beta-adrenergic agonist salbutamol modulates neuromuscular junction formation in zebrafish models of human myasthenic syndromes. Hum Mol Genet 27:1556-1564 (2018). PubMed: 29462491