Human RHEB peptide (ab194764)
Key features and details
- Suitable for: Blocking
製品の詳細
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製品名
Human RHEB peptide
RHEB タンパク質・ペプチド 製品一覧 -
Animal free
No -
由来
Synthetic -
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生物種
Human
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関連製品
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Corresponding Antibody
特性
Our Abpromise guarantee covers the use of ab194764 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Blocking - Blocking peptide for Anti-RHEB antibody [EPR2971] (ab92313)
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製品の状態
Liquid -
備考
- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
- If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
- Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
- Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
- Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use. -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at -20°C long term.
関連情報
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別名
- Ras homolog enriched in brain 2, formerly
- GTP binding protein Rheb
- GTP-binding protein Rheb
see all -
機能
Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity. -
組織特異性
Ubiquitous. Highest levels observed in skeletal and cardiac muscle. -
配列類似性
Belongs to the small GTPase superfamily. Rheb family. -
翻訳後修飾
Farnesylation is important for efficiently activating mTORC1-mediated signaling. -
細胞内局在
Cell membrane. - Information by UniProt
画像
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To learn more about our protein and peptide range click here.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (1)
ab194764 は 1 報の論文で使用されています。
- Agarwal S et al. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res 14:66-77 (2016). Blocking ; Human . PubMed: 26385560