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Products:Signal Transduction >> Protein Trafficking >> Chaperones >> Heat Shock Proteins
Overview
Product name
Anti-Hsp90 antibody
Hsp90 抗体 (21件) 一覧
Description
Rabbit polyclonal to Hsp90
Specificity
ab19021 recognizes Hsp90α and Hsp90β.
Tested applications
WB, IP, IHC-Frmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide corresponding to residues surrounding amino acids 714 of human Hsp90.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, 1.0% BSA, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Tumor biomarkers >> Other
Signal Transduction >> Protein Trafficking >> Chaperones >> Heat Shock Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab19021 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 2 µg/ml.Predicted molecular weight: 90 kDa.
IP: Use a concentration of 10 - 20 µg/ml.
IHC-Fr: Use a concentration of 10 - 20 µg/ml.
Target
Relevance
In mammalian cells there are at least two Hsp90 isoforms, Hsp90a and Hsp90b which are encoded by separate genes. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cells powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by nonphysiological conditions. However, in the absence of stress, Hsp90 is a necessary component of fundamental cellular processes such as hormone signaling and cell cycle control. In this context several key regulatory proteins such as steriod receptors, cell cycle kinases involved in signal transduction and p53 have been identified as substrates of Hsp90. It has been suggested that Hsp90 acts as a capacitor for morphological evolution by buffering widespread variation, which may affect morphogenic pathways.
Cellular localization
Cytoplasmic
Alternative names
- D6S182 antibody
- FLJ26984 antibody
- FLJ31884 antibody
see all
Database links
- Entrez Gene: 3320 Human
- Entrez Gene: 3326 Human
- Entrez Gene: 15516 Mouse
- Entrez Gene: 15519 Mouse
- Entrez Gene: 301252 Rat
- Omim: 140571 Human
- Omim: 140572 Human
- SwissProt: P07900 Human
see all
References for Anti-Hsp90 antibody (ab19021)
This product has been referenced in:
- Madrigal-Matute Jet al. Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis. Cardiovasc Res 86:330-7 (2010). WB, IHC-P; Mouse.Read more (PubMed: 20154064) »
- De Jaco Aet al. Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family. J Biol Chem 285:28674-82 (2010). WB; Human.Read more (PubMed: 20615874) »
See all 4 publications for this product
Publishing research using ab19021? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"