Anti-HO-2 抗体 (ab90515)
Key features and details
- Rabbit polyclonal to HO-2
- Suitable for: WB, ICC/IF, IHC-P, IP, ELISA
- Reacts with: Mouse, Rat, Hamster, Dog, Human, Pig, Monkey
- Isotype: IgG
製品の概要
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製品名
Anti-HO-2 antibody
HO-2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to HO-2 -
由来種
Rabbit -
アプリケーション
適用あり: WB, ICC/IF, IHC-P, IP, ELISAmore details -
種交差性
交差種: Mouse, Rat, Hamster, Dog, Human, Pig, Monkey -
免疫原
Synthetic peptide corresponding to Human HO-2 (N terminal).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.09% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab90515の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (3) |
1/1000. Predicted molecular weight: 36 kDa.
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ICC/IF |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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IP |
Use at an assay dependent concentration.
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ELISA |
Use at an assay dependent concentration.
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特記事項 |
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WB
1/1000. Predicted molecular weight: 36 kDa. |
ICC/IF
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
ELISA
Use at an assay dependent concentration. |
ターゲット情報
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機能
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. -
配列類似性
Belongs to the heme oxygenase family.
Contains 2 HRM (heme regulatory motif) repeats. -
細胞内局在
Microsome. Endoplasmic reticulum. - Information by UniProt
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参照データベース
- Entrez Gene: 479864 Dog
- Entrez Gene: 3163 Human
- Entrez Gene: 15369 Mouse
- Entrez Gene: 79239 Rat
- Omim: 141251 Human
- SwissProt: P30519 Human
- SwissProt: O70252 Mouse
- SwissProt: P23711 Rat
see all -
別名
- Heme oxygenase (decycling) 2 antibody
- Heme oxygenase (decyclizing) 2 antibody
- Heme oxygenase 2 antibody
see all
画像
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ab90515 staining HO-2 in MCF7 cells by Immunofluorescence (green). Nuclei are stained in blue pseudocolor using DRAQ5.
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All lanes : Anti-HO-2 antibody (ab90515) at 1/1000 dilution
Lane 1 : HO-2 Recombinant Human Protein
Lane 2 : Human Liver Microsome Extract
Lane 3 : Mouse Liver Microsome Extract
Lane 4 : Rat Liver Microsome Extract
Lane 5 : Dog Liver Microsome Extract
Predicted band size: 36 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab90515 は 5 報の論文で使用されています。
- Hanna DA et al. Heme oxygenase-2 (HO-2) binds and buffers labile ferric heme in human embryonic kidney cells. J Biol Chem 298:101549 (2022). PubMed: 34973332
- Patra U et al. Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription Units. Oxid Med Cell Longev 2020:7289120 (2020). PubMed: 32322337
- Liu L et al. Heme oxygenase-2 is post-translationally regulated by heme occupancy in the catalytic site. J Biol Chem 295:17227-17240 (2020). PubMed: 33051205
- Yang F et al. Suppression of TRPV4 channels ameliorates anti-dipsogenic effects under hypoxia in the subfornical organ of rats. Sci Rep 6:30168 (2016). WB . PubMed: 27436489
- Lee S et al. Chronic Stress Decreases Cerebrovascular Responses During Rat Hindlimb Electrical Stimulation. Front Neurosci 9:462 (2015). WB ; Rat . PubMed: 26778944