Anti-HDAC6 (phospho S22) 抗体 (ab61058)
Key features and details
- Rabbit polyclonal to HDAC6 (phospho S22)
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-HDAC6 (phospho S22) antibody
HDAC6 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to HDAC6 (phospho S22) -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human HDAC6 aa 1-100 (phospho S22).
Database link: Q9UBN7 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.87% Sodium chloride
Without Mg2+ and Ca2+ -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
ab61058 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab61058の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P | (1) |
1/50 - 1/100.
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特記事項 |
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IHC-P
1/50 - 1/100. |
ターゲット情報
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機能
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. -
配列類似性
Belongs to the histone deacetylase family. HD type 2 subfamily.
Contains 1 UBP-type zinc finger. -
翻訳後修飾
Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
Sumoylated in vitro. -
細胞内局在
Nucleus. Cytoplasm. It is mainly cytoplasmic, where it is associated with microtubules. - Information by UniProt
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参照データベース
- Entrez Gene: 10013 Human
- Omim: 300272 Human
- SwissProt: Q9UBN7 Human
- Unigene: 6764 Human
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別名
- CPBHM antibody
- FLJ16239 antibody
- HD 6 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab61058 は 4 報の論文で使用されています。
- Tseng JH et al. Tau seeds are subject to aberrant modifications resulting in distinct signatures. Cell Rep 35:109037 (2021). PubMed: 33910013
- Lin CH et al. A dual inhibitor targeting HMG-CoA reductase and histone deacetylase mitigates neurite degeneration in LRRK2-G2019S parkinsonism. Aging (Albany NY) 12:25581-25598 (2020). PubMed: 33231564
- Hathaway QA et al. Maternal-engineered nanomaterial exposure disrupts progeny cardiac function and bioenergetics. Am J Physiol Heart Circ Physiol 312:H446-H458 (2017). PubMed: 28011589
- Chen S et al. HDAC6 regulates mitochondrial transport in hippocampal neurons. PLoS One 5:e10848 (2010). PubMed: 20520769