Anti-GTF2IRD1 抗体 (ab64805)
Key features and details
- Rabbit polyclonal to GTF2IRD1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-GTF2IRD1 antibody -
製品の詳細
Rabbit polyclonal to GTF2IRD1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
A synthetic peptide derived from N terminus of human GTF2IRD1.
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ポジティブ・コントロール
- Extracts from 293 cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab64805の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa).
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特記事項 |
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WB
1/500 - 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa). |
ターゲット情報
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機能
May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8. -
組織特異性
Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested. -
関連疾患
Note=GTF2IRD1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2IRD1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. -
配列類似性
Belongs to the TFII-I family.
Contains 5 GTF2I-like repeats. -
発生段階
Highly expressed in developing and regenerating muscles, at the time of myofiber diversification. -
ドメイン
The N-terminal half may have an activating activity. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 9569 Human
- Entrez Gene: 57080 Mouse
- Entrez Gene: 246770 Rat
- Omim: 604318 Human
- SwissProt: Q6DSU6 Human
- SwissProt: Q9UHL9 Human
- SwissProt: Q9JI57 Mouse
- Unigene: 647056 Human
see all -
別名
- CREAM1 antibody
- General transcription factor II I repeat domain containing protein 1 antibody
- General transcription factor II-I repeat domain-containing protein 1 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab64805 は 1 報の論文で使用されています。
- Masuda T et al. The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina. J Neurosci 34:15356-68 (2014). WB, IP, IHC ; Mouse . PubMed: 25392503