Anti-GPCR GPR15 抗体 (ab8104)
Key features and details
- Rabbit polyclonal to GPCR GPR15
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-GPCR GPR15 antibody
GPCR GPR15 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to GPCR GPR15 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human GPCR GPR15 aa 1-100.
(Peptide available asab6101) -
特記事項
Human immunodeficiency virus (HIV) and related viruses require co-receptors to infect target cells. Some G protein coupled receptors including CCR5, CXCR4, CCR3,CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. The genes encoding human and monkey GPR15/BOB (for G protein-coupled receptor 15 and brother of Bonzo, respectively) were recently cloned. This novel G protein-coupled receptor serves as coreceptor for simian immunodeficiency virus (SIV), and for strains of HIV-2 and M-tropic HIV-1. The ligand for GPR15 has not been identified yet.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide -
Concentration information loading...
-
精製度
Immunogen affinity purified -
一次抗体 備考
Human immunodeficiency virus (HIV) and related viruses require co-receptors to infect target cells. Some G protein coupled receptors including CCR5, CXCR4, CCR3,CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. The genes encoding human and monkey GPR15/BOB (for G protein-coupled receptor 15 and brother of Bonzo, respectively) were recently cloned. This novel G protein-coupled receptor serves as coreceptor for simian immunodeficiency virus (SIV), and for strains of HIV-2 and M-tropic HIV-1. The ligand for GPR15 has not been identified yet. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab8104の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
1/500 - 1/2000. Detects a band of approximately 50 kDa.
|
特記事項 |
---|
WB
1/500 - 1/2000. Detects a band of approximately 50 kDa. |
ターゲット情報
-
機能
Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
細胞内局在
Cell membrane. - Information by UniProt
-
参照データベース
- Entrez Gene: 2838 Human
- Omim: 601166 Human
- SwissProt: P49685 Human
- Unigene: 563128 Human
-
別名
- BOB antibody
- Brother of Bonzo antibody
- G protein coupled receptor 15 antibody
see all
画像
-
All lanes : Anti-GPCR GPR15 antibody (ab8104)
Lane 1 : Human heart lysate in absence of specific peptide
Lane 2 : Human heart lysate in presence of specific peptide
Lane 3 : Human heart lysate in presence of unrelated peptide
Observed band size: 50 kDa why is the actual band size different from the predicted?
Western blot analysis of GPR15 in human heart lysate with anti- GPR15 (NT) in the absence (lane 1) or presence of specific peptide (lane 2) or non related peptide (lane 3). -
Lane 1 : Anti-GPCR GPR15 antibody (ab8104) at 0.5 µg/ml
Lane 2 : Anti-GPCR GPR15 antibody (ab8104) at 1 µg/ml
All lanes : Human spleen lysate
Observed band size: 50 kDa why is the actual band size different from the predicted?
データシートおよび資料
-
Datasheet download
参考文献 (3)
ab8104 は 3 報の論文で使用されています。
- Furukawa K et al. Recombinant Thrombomodulin Has Anti-tumor Effects and Enhances the Effects of Gemcitabine for Pancreatic Cancer Through G-protein Coupled Receptor 15. Anticancer Res 42:4679-4687 (2022). PubMed: 36191971
- Pan B et al. G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin. Sci Rep 7:692 (2017). WB . PubMed: 28386128
- Pan B et al. The Fifth Epidermal Growth Factor-like Region of Thrombomodulin Alleviates Murine Graft-versus-Host Disease in a G-Protein Coupled Receptor 15 Dependent Manner. Biol Blood Marrow Transplant 23:746-756 (2017). PubMed: 28167153