GF 109203X hydrochloride, ATP-competitive PKC inhibitor (ab120844)
Key features and details
- Potent, cell-permeable, ATP-competitive PKC inhibitor
- CAS Number: 176504-36-2
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
GF 109203X hydrochloride, ATP-competitive PKC inhibitor -
製品の詳細
Potent, cell-permeable, ATP-competitive PKC inhibitor -
生理活性の詳細
Potent, cell-permeable, ATP-competitive PKC inhibitor (IC50 values for PKC subtypes are 50 (α), 17 (βI), 16 (βII) and 20 nM (γ)). Inhibits PKC over other kinases (IC50 values are 50 nM (MAPKAP), 100 nM (p70 S6 kinase), 2 μM (cAMP-dependent protein kinase) and 0.7 μM (phosphorylase kinase)). Crosses the blood-brain barrier.
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精製度
> 98% -
CAS 番号
176504-36-2 -
構造式
製品の特性
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体系名
3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride -
分子量
448.95 -
分子式
C25H24N4O2.HCl -
PubChem 登録番号
6419775 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54.Cl -
由来
Synthetic
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研究分野
関連製品
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プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120844 は 1 報の論文で使用されています。
- Zhang H et al. Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. J Neurochem 161:478-491 (2022). PubMed: 35583089