Anti-GABRD 抗体 (ab110014)
Key features and details
- Rabbit polyclonal to GABRD
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-GABRD antibody
GABRD 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to GABRD -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Human GABRD (internal sequence).
-
ポジティブ・コントロール
- Extracts from LOVO or HT29 cells
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
-
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab110014の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
1/500 - 1/1000. Predicted molecular weight: 50 kDa.
|
特記事項 |
---|
WB
1/500 - 1/1000. Predicted molecular weight: 50 kDa. |
ターゲット情報
-
機能
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. -
関連疾患
Defects in GABRD are the cause of susceptibility to generalized epilepsy with febrile seizures plus type 5 (GEFS+5) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
Defects in GABRD are the cause of susceptibility to idiopathic generalized epilepsy type 10 (IGE10) [MIM:613060]. A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain.
Defects in GABRD are the cause of susceptibility to juvenile myoclonic epilepsy type 7 (EJM7) [MIM:613060]. A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. -
配列類似性
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily. -
細胞内局在
Cell junction > synapse > postsynaptic cell membrane. Cell membrane. - Information by UniProt
-
参照データベース
- Entrez Gene: 2563 Human
- Entrez Gene: 14403 Mouse
- Entrez Gene: 29689 Rat
- Omim: 137163 Human
- SwissProt: O14764 Human
- SwissProt: P22933 Mouse
- SwissProt: P18506 Rat
- Unigene: 113882 Human
see all -
別名
- GABA(A) receptor subunit delta antibody
- Gabrd antibody
- Gamma aminobutyric acid GABA A receptor delta antibody
see all
画像
-
All lanes : Anti-GABRD antibody (ab110014) at 1/500 dilution
Lane 1 : extracts from HT29 cells (5-30 ug total protein) with no immunizing peptide
Lane 2 : extracts from LOVO cells (5-30 ug total protein) with no immunizing peptide
Lane 3 : extracts from LOVO cells (5-30 ug total protein) with immunizing peptide (5-10 ug)
Predicted band size: 50 kDa
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (5)
ab110014 は 5 報の論文で使用されています。
- Shen H et al. Increased Dendritic Branching of and Reduced d-GABAA Receptor Expression on Parvalbumin-Positive Interneurons Increase Inhibitory Currents and Reduce Synaptic Plasticity at Puberty in Female Mouse CA1 Hippocampus. Front Cell Neurosci 14:203 (2020). PubMed: 32733208
- Zheng J et al. Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. Cell Stem Cell 26:331-345.e6 (2020). PubMed: 31978364
- Fatemi SH et al. GABAA and GABAB receptor dysregulation in superior frontal cortex of subjects with schizophrenia and bipolar disorder. Synapse 71:N/A (2017). PubMed: 28316115
- Chen M et al. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. Elife 6:N/A (2017). WB ; Mouse . PubMed: 28054918
- Fatemi SH et al. The effects of prenatal H1N1 infection at E16 on FMRP, glutamate, GABA, and reelin signaling systems in developing murine cerebellum. J Neurosci Res 95:1110-1122 (2017). PubMed: 27735078