Anti-FSH-R 抗体 (ab75200)
Key features and details
- Rabbit polyclonal to FSH-R
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-FSH-R antibody
FSH-R 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to FSH-R -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Human FSH-R (internal sequence).
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ポジティブ・コントロール
- Transfected Jurkat and HUVEC cell extracts
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg2+ and Ca2+ -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
Affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab75200の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 78 kDa.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 78 kDa. |
ターゲット情報
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機能
Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. -
組織特異性
Sertoli cells and ovarian granulosa cells. -
関連疾患
Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain. -
翻訳後修飾
N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2492 Human
- Entrez Gene: 14309 Mouse
- Entrez Gene: 25449 Rat
- Omim: 136435 Human
- SwissProt: P23945 Human
- SwissProt: P35378 Mouse
- SwissProt: P20395 Rat
- Unigene: 1428 Human
see all -
別名
- Follicle stimulating hormone receptor antibody
- Follicle stimulating hormone receptor isoform 1 antibody
- Follicle-stimulating hormone receptor antibody
see all
画像
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All lanes : Anti-FSH-R antibody (ab75200) at 1/500 dilution
Lane 1 : Transfected Jurkat cell extract
Lane 2 : Transfected HUVEC cell extract
Lane 3 : Transfected Jurkat cell extract with immunising peptide at 10 µg
Lysates/proteins at 10 µg per lane.
Predicted band size: 78 kDa
Observed band size: 78 kDa
Additional bands at: 85 kDa. We are unsure as to the identity of these extra bands.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (12)
ab75200 は 12 報の論文で使用されています。
- Sheng S et al. Follicle-Stimulating Hormone Promotes the Development of Endometrial Cancer In Vitro and In Vivo. Int J Environ Res Public Health 19:N/A (2022). PubMed: 36430063
- Ebrahim N et al. Bone marrow-derived mesenchymal stem cells combined with gonadotropin therapy restore postnatal oogenesis of chemo-ablated ovaries in rats via enhancing very small embryonic-like stem cells. Stem Cell Res Ther 12:517 (2021). PubMed: 34579781
- Tao J et al. Effect of Exogenous Melatonin on the Development of Mice Ovarian Follicles and Follicular Angiogenesis. Int J Mol Sci 22:N/A (2021). PubMed: 34681919
- Hau RK et al. Generation of a hTERT-Immortalized Human Sertoli Cell Model to Study Transporter Dynamics at the Blood-Testis Barrier. Pharmaceutics 12:N/A (2020). PubMed: 33105674
- Zhang J et al. ACTL6A regulates follicle-stimulating hormone-driven glycolysis in ovarian cancer cells via PGK1. Cell Death Dis 10:811 (2019). PubMed: 31649264