Anti-FRK 抗体 [4E1] (ab91623)
Key features and details
- Mouse monoclonal [4E1] to FRK
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-FRK antibody [4E1]
FRK 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [4E1] to FRK -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Purified recombinant fragment of Human FRK expressed in E. Coli.
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ポジティブ・コントロール
- K562 cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.05% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
Purified from tissue culture supernatant. -
ポリ/モノ
モノクローナル -
クローン名
4E1 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab91623の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/2000. Predicted molecular weight: 58 kDa.
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特記事項 |
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WB
1/500 - 1/2000. Predicted molecular weight: 58 kDa. |
ターゲット情報
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機能
Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation possibly by reducing its binding to NEDD4. May function as a tumor suppressor. -
組織特異性
Restricted to cells lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. -
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 2444 Human
- Omim: 606573 Human
- SwissProt: P42685 Human
- Unigene: 89426 Human
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別名
- Beta cell Src homology tyrosine kinase antibody
- BSK antibody
- BSK/IYK antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (1)
ab91623 は 1 報の論文で使用されています。
- de Wispelaere M et al. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol 87:7367-81 (2013). PubMed: 23616652