Anti-FREM1 抗体 (ab117566)
Key features and details
- Rabbit polyclonal to FREM1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-FREM1 antibody
FREM1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to FREM1 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Synthetic peptide corresponding to Human FREM1 (C terminal) conjugated to keyhole limpet haemocyanin. KLH. A 15 AA synthetic peptide. The immunogen is located within the last 50 AA of FREM1.
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ポジティブ・コントロール
- Human tonsil tissue.
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特記事項
Based on the location of the immunogen the antibody can detect FREM 1 isoform 1 and isoform 2 (also known as TILRR).
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab117566の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
Use a concentration of 10 µg/ml.
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特記事項 |
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IHC-P
Use a concentration of 10 µg/ml. |
ターゲット情報
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機能
Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development. -
関連疾患
Defects in FREM1 are the cause of bifid nose with or without anorectal and renal anomalies (BNAR) [MIM:608980]. A bifid nose is a rare congenital deformity due to failure of the paired nasal processes to fuse to a single midline organ during early gestation. BNAR is an autosomal recessive disorder and patients usually present a bifid nose associated with renal and anorectal malformations. -
配列類似性
Belongs to the FRAS1 family.
Contains 1 C-type lectin domain.
Contains 1 Calx-beta domain.
Contains 12 CSPG (NG2) repeats. -
ドメイン
The Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding. -
細胞内局在
Secreted > extracellular space > extracellular matrix > basement membrane. Localizes at the basement membrane zone of embryonic epidermis and hair follicles. - Information by UniProt
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参照データベース
- Entrez Gene: 158326 Human
- Entrez Gene: 329872 Mouse
- Omim: 608944 Human
- SwissProt: Q5H8C1 Human
- SwissProt: Q684R7 Mouse
- Unigene: 50850 Human
- Unigene: 242337 Mouse
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別名
- BC037594 antibody
- BNAR antibody
- C9orf143 antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (0)
ab117566 は論文での使用が確認できていません。