Anti-FACL4 抗体 (ab110007)
Key features and details
- Goat polyclonal to FACL4
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-FACL4 antibody
FACL4 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to FACL4 -
由来種
Goat -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Cow, Dog, Pig -
免疫原
Synthetic peptide: C-
HYLKDIERMYGGK
, corresponding to C terminal amino acids 699-711 of Human FACL4 -
ポジティブ・コントロール
- Human brain (cortex) tissue, Human small intestine tissue, HepG2 cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab110007の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 79 kDa.
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IHC-P |
Use a concentration of 3.75 µg/ml.
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特記事項 |
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WB
Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 79 kDa. |
IHC-P
Use a concentration of 3.75 µg/ml. |
ターゲット情報
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機能
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. -
関連疾患
Defects in ACSL4 are the cause of mental retardation X-linked type 63 (MRX63) [MIM:300387]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR) [MIM:300194]. A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. -
配列類似性
Belongs to the ATP-dependent AMP-binding enzyme family. -
細胞内局在
Mitochondrion outer membrane. Peroxisome membrane. Microsome membrane. Endoplasmic reticulum membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 536628 Cow
- Entrez Gene: 481018 Dog
- Entrez Gene: 2182 Human
- Entrez Gene: 50790 Mouse
- Entrez Gene: 448980 Pig
- Entrez Gene: 113976 Rat
- Omim: 300157 Human
- SwissProt: O60488 Human
see all -
別名
- ACS 4 antibody
- ACS4 antibody
- ACSL 4 antibody
see all
画像
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ab110007, at 3.75 µg/ml, staining FACL4 in human brain (cortex) tissue by immunohistochemistry.
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ab110007, at 3.75 µg/ml, staining FACL4 in Human small intestine tissue by immunohistochemistry.
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Anti-FACL4 antibody (ab110007) at 0.1 µg/ml + HepG2 cell lysate in RIPA buffer at 35 µg
Predicted band size: 79 kDa
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (5)
ab110007 は 5 報の論文で使用されています。
- Zhang L et al. S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis. Cell Mol Gastroenterol Hepatol 11:697-724 (2021). PubMed: 33075563
- Fan Y et al. Identification of Milk Fat Metabolism-Related Pathways of the Bovine Mammary Gland during Mid and Late Lactation and Functional Verification of the ACSL4 Gene. Genes (Basel) 11:N/A (2020). PubMed: 33207796
- Wang J et al. The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of hepatocellular carcinoma. Aging (Albany NY) 12:7786-7800 (2020). PubMed: 32357142
- Sun XJ & Xu GL Overexpression of Acyl-CoA Ligase 4 (ACSL4) in Patients with Hepatocellular Carcinoma and its Prognosis. Med Sci Monit 23:4343-4350 (2017). PubMed: 28887439
- Lynes EM et al. Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling. J Cell Sci 126:3893-903 (2013). PubMed: 23843619