Esomeprazole sodium, H+/ K+-ATPase (proton pump) inhibitor (ab120500)
Key features and details
- H+/ K+-ATPase (proton pump) inhibitor
- CAS Number: 161796-78-7
- Soluble in water to 100 mM, in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Esomeprazole sodium, H+/ K+-ATPase (proton pump) inhibitor -
製品の詳細
H+/ K+-ATPase (proton pump) inhibitor -
生理活性の詳細
H+ / K+-ATPase (proton pump) inhibitor (IC50 = 2.3 µM). S-enantiomer of omeprazole. Attenuates intestinal mucosal barrier damage and can promote healing of gastric lesions in rats. Also inhibits Cytochrome P450 2C19 (CYP2C9), CYP2C19 and CYP3A4 (Ki values are 81.5, 8.6 and 46.6 µM, respectively).
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CAS 番号
161796-78-7 -
構造式
製品の特性
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体系名
6-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt -
分子量
367.40 -
分子式
C17H18N3NaO3S -
PubChem 登録番号
23674541 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM, in ethanol to 100 mM and in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
[Na+].Cc3c(OC)c(C)cnc3CS(=O)c1[n-]c2cc(ccc2n1)OC -
由来
Synthetic
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研究分野
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab120500の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Functional Studies |
Use at an assay dependent concentration.
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特記事項 |
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Functional Studies
Use at an assay dependent concentration. |
画像
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2D chemical structure image of ab120500, Esomeprazole sodium, H+/ K+-ATPase (proton pump) inhibitor
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MDA-MB-231 cells were incubated at 37°C for 6h with vehicle control (0 µM) and 100 µM of esomeprazole sodium (ab120500). Increased expression of aryl hydrocarbon receptor (ab2770) correlates with an increase in esomeprazole sodium concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab2770 at 2 µg/ml and ab8226 at 1 µg/ml overnight at 4°C. Antibody binding was detected using an anti-mouse antibody conjugated to HRP (ab97040) at 1/10000 dilution and visualised using ECL development solution.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (0)
ab120500 は論文での使用が確認できていません。