Anti-EYA2 抗体 [EPR2942] (ab92505)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR2942] to EYA2
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
-
製品名
Anti-EYA2 antibody [EPR2942]
EYA2 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR2942] to EYA2 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: Flow Cyt,ICC/IF or IHC-P -
種交差性
交差種: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
ポジティブ・コントロール
- Y-79 cell lysate and 293T cell lysate
-
特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading...
-
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR2942 -
アイソタイプ
IgG -
研究分野
関連製品
-
Alternative Versions
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab92505の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
1/50000 - 1/200000. Predicted molecular weight: 59 kDa.
|
特記事項 |
---|
WB
1/50000 - 1/200000. Predicted molecular weight: 59 kDa. |
ターゲット情報
-
機能
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity. -
組織特異性
Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart. -
配列類似性
Belongs to the HAD-like hydrolase superfamily. EYA family. -
発生段階
At the begin of fourth week of development detected in cytoplasm of somite cells. Between the sixth and eighth week of development detected in cytoplasm of limb bud cells. -
細胞内局在
Cytoplasm. Nucleus. - Information by UniProt
-
参照データベース
- Entrez Gene: 2139 Human
- Omim: 601654 Human
- SwissProt: O00167 Human
- Unigene: 472877 Human
- Unigene: 722040 Human
- Unigene: 722415 Human
- Unigene: 722416 Human
-
別名
- EAB 1 antibody
- EAB1 antibody
- EYA 2 antibody
see all
画像
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (1)
ab92505 は 1 報の論文で使用されています。
- Kohrt D et al. CDK6 binds and promotes the degradation of the EYA2 protein. Cell Cycle 13:62-71 (2014). WB, IP . PubMed: 24196439